The role of genetic variants in human longevity.
The role of genetic variants in human longevity.
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DOI：
10.1016/j.arr.2010.08.001
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发表时间：
2010-11
影响因子：
13.1
通讯作者：
Hung SI
中科院分区：
文献类型：
--
作者：
Chung WH;Dao RL;Chen LK;Hung SI
胰岛素/胰岛素样生长因子-1（IIS）信号通路的遗传多态性影响人类寿命。FOXO 3A的变异体与不同人群的寿命有关。参与脂蛋白代谢和细胞周期调节因子的基因变体有助于人类长寿。人类长寿是一个具有强烈遗传倾向的复杂表型。越来越多的证据揭示了人类长寿的遗传因素。本文旨在回顾各种病例/对照关联研究的数据，这些研究检查了不同人群中长寿人群和年轻受试者之间遗传多态性的差异。有100多个候选基因可能与人类长寿有关;本文特别关注胰岛素/IGF-1途径、FOXO 3A、FOXO 1A、脂蛋白代谢（例如，APOE和PON 1）和细胞周期调节剂（例如，TP 53和P21）。由于迄今为止已证实的人类长寿遗传因素很少，因此需要对遗传因素作进一步的精确评估。更好地了解遗传学对人类寿命的贡献可能有助于设计改进的年龄相关疾病治疗方法，延缓衰老过程，并最终延长人类寿命。
▶ Genetic polymorphisms of insulin/insulin-like growth factor-1 (IIS) signaling pathway influence human longevity. ▶ Variants of FOXO3A link to longevity across different human populations. ▶ Variants of genes involved in lipoprotein metabolism, and cell-cycle regulators contribute to human longevity. Human longevity is a complex phenotype with a strong genetic predisposition. Increasing evidence has revealed the genetic antecedents of human longevity. This article aims to review the data of various case/control association studies that examine the difference in genetic polymorphisms between long-lived people and younger subjects across different human populations. There are more than 100 candidate genes potentially involved in human longevity; this article particularly focuses on genes of the insulin/IGF-1 pathway, FOXO3A, FOXO1A, lipoprotein metabolism (e.g., APOE and PON1), and cell-cycle regulators (e.g., TP53 and P21). Since the confirmed genetic components for human longevity are few to date, further precise assessment of the genetic contributions is required. Gaining a better understanding of the contribution of genetics to human longevity may assist in the design of improved treatment methods for age-related diseases, delay the aging process, and, ultimately, prolong the human lifespan.
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影响因子：
3.9
作者：
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通讯作者：
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作者：
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作者：
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DOI：
10.1073/pnas.97.8.4291
发表时间：
2000-04-11
影响因子：
11.1
作者：
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通讯作者：
Roninson, IB