Neural dysfunction and violence in schizophrenia: An fMRI investigation
Neural dysfunction and violence in schizophrenia: An fMRI investigation
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DOI：
10.1016/j.schres.2006.02.017
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发表时间：
2006-05-01
影响因子：
4.5
通讯作者：
Sharma, Tonmoy
中科院分区：
文献类型：
--
作者：
Kumari, Veena;Aasen, Ingrid;Sharma, Tonmoy
当代理论和证据表明，额叶功能障碍与暴力行为以及精神分裂症有关。我们应用功能性磁共振成像（fMRI）来研究和比较患有（i）精神分裂症和严重身体暴力史的男性在“n-back”工作记忆任务中的大脑激活（VS; n = 13），（ii）无暴力史的精神分裂症（NVS：n = 12），（iii）反社会人格障碍（APD）和严重身体暴力史（n = 10），（iv）无暴力史或精神障碍（n = 13）。我们在对照（0-back）条件下观察到所有四组的性能相当。NVS组和APD组的工作记忆缺陷较轻微，而VS组的工作记忆缺陷较严重。在工作记忆负荷条件下，与健康组相比，VS组双侧额叶和楔前叶均表现出激活缺陷，与NVS组相比，VS组右侧顶下区也表现出激活缺陷。额叶（双侧）以及右下顶叶活动与所有精神分裂症患者的暴力评分呈负相关，右顶叶区域显示出最强烈的这种关联。与正常人相比，APD患者的左侧额回、前扣带回和楔前叶的激活缺陷明显。它的结论是减少功能反应在额叶和顶叶下区导致严重的暴力精神分裂症可能通过受损的执行功能。(c)2006 Elsevier B. V.保留所有权利。
Contemporary theories and evidence implicate frontal lobe dysfunction in violent behaviour as well as in schizophrenia. We applied functional magnetic resonance imaging (fMRI) to investigate and compare brain activation during an 'n-back' working memory task in groups of men with (i) schizophrenia and a history of serious physical violence (VS; n = 13), (ii) schizophrenia without a history of violence (NVS: n = 12), (iii) antisocial personality disorder (APD) and a history of serious physical violence (n = 10), and (iv) no history of violence or a mental disorder (n = 13). We observed comparable performance in all four groups during the control (0-back) condition. Subtle working memory deficits were seen in the NVS and APD groups but severe deficits emerged in the VS group relative to the healthy group. The VS group showed activation deficit bilaterally in the frontal lobe and precuneus when compared to the healthy group, and in the right inferior parietal region when compared to the NVS group during the working memory load condition. Frontal (bilateral) as well as right inferior parietal activity was negatively associated with the ratings of violence across all schizophrenia patients, with the right parietal region showing this association most strongly. APD patients, relative to healthy subjects, showed activation deficit in the left frontal gyrus, anterior cingulate and precuneus. It is concluded that reduced functional response in the frontal and inferior parietal regions leads to serious violence in schizophrenia perhaps via impaired executive functioning. (c) 2006 Elsevier B.V. All rights reserved.