Complex activities of daily living vary by mild cognitive impairment subtype.
Complex activities of daily living vary by mild cognitive impairment subtype.
复制标题
DOI：
10.1017/s1355617710000330
复制
发表时间：
2010-07
影响因子：
2.6
通讯作者：
Bondi, Mark W.
中科院分区：
文献类型：
--
作者：
Bangen, Katherine J.;Jak, Amy J.;Schiehser, Dawn M.;Delano-Wood, Lisa;Tuminello, Elizabeth;Han, S. Duke;Delis, Dean C.;Bondi, Mark W.
关键词：
越来越多的人一致认为，对轻度认知障碍(MCI)的功能衰退进行手术定义和测量具有重要意义。然而，很少有研究直接研究MCI或其推测的亚型的功能能力，到目前为止，报道的结果还不一致。非痴呆症老年人(n=120)接受了一项全面的认知成套测验，测量了多个领域，并进行了基于表现的功能能力测量。参与者的特征是认知正常、遗忘性MCI或非遗忘性MCI。与认知正常的人相比，MCI患者的日常生活工具性活动(IADL)明显减少。具体地说，患有遗忘性MCI的参与者在财务管理方面表现出显著的下降，而那些没有遗忘性MCI的参与者在与健康和安全相关的能力方面表现得更差。此外，功能能力的下降与MCI参与者的整体认知功能的下降有关，但与记忆或执行功能的下降无关。Logistic回归分析表明，功能能力能准确预测MCI亚型。结果支持需要更好地描述MCI的功能衰退。鉴于功能状态对MCI诊断和治疗的影响，建议直接评估功能能力。结果进一步表明，基于成绩的IADL评估在区分MCI亚型方面可能有实用价值。
There is increasing consensus regarding the importance of operationally defining and measuring functional decline in mild cognitive impairment (MCI). However, few studies have directly examined functional abilities in MCI or its presumed subtypes and, to date, reported findings have been discrepant. Nondemented older adults (n = 120) were administered a comprehensive cognitive battery measuring multiple domains as well as a performance-based functional ability measure. Participants were characterized as either cognitively normal, amnestic MCI, or non-amnestic MCI. MCI individuals demonstrated decrements in instrumental activities of daily living (IADL) relative to their cognitively normal counterparts. Specifically, participants with amnestic MCI demonstrated significant decrements in financial management, whereas those with non-amnestic MCI showed poorer performance in abilities related to health and safety. Moreover, decreased functional abilities were associated with decrements in global cognitive functioning but not memory or executive functions in the MCI participants. Finally, logistic regression demonstrated that functional abilities accurately predicted MCI subtype. Results support the need for better delineation of functional decline in MCI. Given the implications of functional status for MCI diagnosis and treatment, the direct assessment of functional abilities is recommended. Results further suggest performance-based IADL assessment may have utility in distinguishing MCI subtypes.