Is there a role for T-type calcium channels in peripheral and central pain sensitization?
Is there a role for T-type calcium channels in peripheral and central pain sensitization?
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T型钙通道在外周和中枢疼痛敏化中是否起作用？
DOI：
10.1385/mn:34:3:243
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发表时间：
2006-12-01
影响因子：
5.1
通讯作者：
Todorovic, Slobodan M.
中科院分区：
文献类型：
--
作者：
Nelson, Michael T.;Todorovic, Slobodan M.
在组织损伤后，外周和中枢感觉神经元都可以变得过度兴奋，或“致敏”。“致敏可导致痛觉长期病理变化。由于许多慢性疼痛状况对大多数目前可用的治疗是难治的，因此对鉴定有助于感觉神经元致敏的分子靶点有很大的兴趣。其中，几类离子通道已成为潜在的目标。最近的体外和体内研究已经证明T型Ca 2+通道在感觉通路中的作用，并表明这些通道可能有助于疼痛处理和致敏。因此，T型通道可能代表了开发新型疼痛疗法的机会，并可能有助于解决未满足的医疗需求。
Following tissue injury, both peripheral and central sensory neurons can become hyperexcitable, or " sensitized." Sensitization can lead to long- term pathological changes in pain sensation. Because many chronic pain conditions are refractory to most currently available treatments, there is great interest in identifying molecular targets that contribute to the sensitization of sensory neurons. Among these, several classes of ion channels have emerged as potential targets. Recent in vitro and in vivo studies have demonstrated a role for T- type Ca2+ channels in sensory pathways and have suggested that these channels may contribute to pain processing and sensitization. Therefore, T- type channels may represent an opportunity for the development of novel pain therapeutics and may help to address an unmet medical need.