Radiologic and histopathologic evaluation of canine artery occlusion after collagen-coated platinum microcoil delivery.
Radiologic and histopathologic evaluation of canine artery occlusion after collagen-coated platinum microcoil delivery.
复制标题
胶原涂层铂微线圈输送后犬动脉闭塞的放射学和组织病理学评估。
DOI：
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Ryuichi Tanaka
中科院分区：
文献类型：
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作者：
S. Tamatani;T. Ozawa;T. Minakawa;S. Takeuchi;T. Koike;Ryuichi Tanaka
背景和目的
铂弹簧圈栓塞是近十年来神经放射学介入技术的重大进展之一。我们的目的是评价胶原涂层铂微弹簧圈在犬动脉中输送的血管造影和组织学影响。
方法
我们栓塞了18只狗的双侧上颌动脉;每只狗使用一个无涂层和一个胶原预充弹簧圈。我们在栓塞后30分钟内通过血管造影、肉眼检查和扫描电子显微镜对所有弹簧圈进行了评价。然后，我们研究了术后1天或3天，或术后1周、2周、3周、4周、8周、12周或16周的涂层和胶原预充弹簧圈的比例。
结果
用无涂层弹簧圈栓塞的18条动脉中有6条（33%）在输送后30分钟闭塞，而用胶原预充弹簧圈治疗的18条动脉中有11条（61%）在栓塞后30分钟内闭塞。晚期闭塞（栓塞后3周）发生在未处理弹簧圈栓塞的8支动脉中的2支（25%）和胶原预充弹簧圈栓塞的8支动脉中的6支（75%）。我们通过卡方检验计算了晚期闭塞率的差异，发现这些差异具有显著性（P= 0.04）。未预充弹簧圈栓塞动脉的组织学结果显示，弹簧圈输送后4周，内皮细胞生长仅限于机化血栓。相反，术后3天内皮细胞直接在胶原预充的弹簧圈上生长，2周内弹簧圈完全被内皮细胞覆盖。我们在血管造影闭塞的动脉中发现了弹簧圈内部空间的机化血栓，这一发现在血管造影通畅的动脉中并不明显。
结论
胶原涂层铂弹簧圈可以快速稳定地闭塞栓塞血管。
BACKGROUND AND PURPOSE
Platinum coil embolization is one of the significant advances in interventional neuroradiologic techniques that has been introduced this decade. Our purpose was to evaluate the angiographic and histologic effects of collagen-coated platinum microcoil delivery in the canine artery.
METHODS
We embolized the bilateral internal maxillary arteries of 18 dogs; one uncoated and one collagen-primed coil was used in each dog. We evaluated all coils by angiography, macroscopy, and scanning electron microscopy within 30 minutes of embolization. We then studied a proportional number of coated and collagen-primed coils at either 1 or 3 days, or 1, 2, 3, 4, 8, 12, or 16 weeks postoperatively.
RESULTS
Six (33%) of 18 arteries embolized with uncoated coils were occluded 30 minutes after delivery, whereas 11 (61%) of 18 arteries treated with collagen-primed coils were occluded within 30 minutes of embolization. Late occlusion (3 weeks after embolization) occurred in 2 (25%) of 8 arteries embolized with untreated coils, and 6 (75%) of 8 arteries embolized with collagen-primed coils. We calculated differences in late occlusion rates by the chi2 (chi-square) test, and found these differences were significant (P=.04). Histologic findings of arteries embolized with unprimed coils revealed endothelial cell growth was limited to the organized thrombi 4 weeks after coil delivery. In contrast, endothelial cells grew directly on the collagen-primed coils 3 days postoperatively, and coils were completely covered by endothelial cells within 2 weeks. We found an organized thrombus in the inner space of coils in angiographically occluded arteries, a finding that was not evident in angiographically patent arteries.
CONCLUSION
Collagen-coated platinum coils can produce rapid and stable occlusion of embolized vessels.
影响因子：
4.1
作者：
GUGLIELMI, G;VINUELA, F;SEPETKA, I
通讯作者：
SEPETKA, I