Urotensin II-immunoreactivity in the brainstem and spinal cord of the rat
Urotensin II-immunoreactivity in the brainstem and spinal cord of the rat
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DOI：
10.1016/s0304-3940(01)01804-3
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发表时间：
2001-06-01
影响因子：
2.5
通讯作者：
Dun, NJ
中科院分区：
文献类型：
--
作者：
Dun, SL;Brailoiu, GC;Dun, NJ
用抗人尾加压素Ⅱ（U-II）肽的抗血清研究了U-II免疫反应性（irU-Ⅱ）在大鼠脑干和脊髓中的分布。脊髓，舌下神经核，迷走神经背侧运动核，面神经运动核，疑核，外展神经核和三叉神经运动核的腹角神经元的人口表现出不同强度的irU-II。irU-II运动神经元的数量在腰段高于颈段、胸段和骶段。双标记的部分与U-II-和胆碱乙酰转移酶（ChAT）-抗血清显示，几乎所有的irU-II腹角和脑干神经元ChAT阳性。结果提供了第一个免疫组化证据irU-II的存在下，胆碱能运动神经元的大鼠脊髓和脑干。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
The distribution of urotensin-II-immunoreactivity (irU-II) was studied in the rat brainstem and spinal cord with the use of an antiserum against the human urotensin II (U-II) peptide. A population of ventral horn neurons in the spinal cord, hypoglossal nucleus, dorsal motor nucleus of the vagus, facial motor nucleus, nucleus ambiguus, abducens nucleus and trigeminal motor nucleus exhibited irU-II of varying intensities. The number of irU-II motor neurons was higher in the lumbar segments as compared to that of cervical, thoracic and sacral segments. Double-labeling the sections with U-II-and choline acetyltransferase (ChAT)-antisera revealed that nearly all irU-ll ventral horn and brainstem neurons were ChAT-positive. The result provides the first immunohistochemical evidence of the presence of irU-II in cholinergic motoneurons of the rat spinal cord and brainstem. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.