BLT1 and BLT2:: the leukotriene B4 receptors
BLT1 and BLT2:: the leukotriene B4 receptors
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DOI：
10.1016/s0952-3278(03)00073-5
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发表时间：
2003-08-01
影响因子：
3
通讯作者：
Luster, AD
中科院分区：
文献类型：
--
作者：
Tager, AM;Luster, AD
白三烯 B-4 (LTB4) 的两种受体已被分子鉴定：BLT1 和 BLT2。两种受体都是 G 蛋白偶联的七跨膜结构域受体，其基因在人类和小鼠基因组中彼此非常接近。这两种受体对 LTB4 的亲和力和特异性不同：BLT1 是 LTB4 特异性的高亲和力受体，而 BLT2 是低亲和力受体，也结合其他类二十烷酸。这两种受体的表达模式也有所不同，BLT1 主要在白细胞中表达，而 BLT2 的表达更为普遍。通过介导 LTB4 的活性，这些受体参与宿主免疫反应和炎症性疾病的发病机制。在使用 LTB4 受体拮抗剂的动物炎症模型和靶向删除 BLT1 的小鼠中观察到疾病严重程度降低，这揭示了 LTB4 及其受体在调节病理性炎症中的重要作用。 (C) 2003 Elsevier Science Ltd. 保留所有权利。
Two receptors for leukotriene B-4 (LTB4) have been molecularly identified: BLT1 and BLT2. Both receptors are G protein-coupled seven transmembrane domain receptors, whose genes are located in very close proximity to each other in the human and mouse genomes. The two receptors differ in their affinity and specificity for LTB4: BLT1 is a high-affinity receptor specific for LTB4, whereas BLT2 is a low-affinity receptor that also binds other eicosanoids. The two receptors also differ in their pattern of expression with BLT1 being expressed primarily in leukocytes, whereas BLT2 is expressed more ubiquitously. By mediating the activities of LTB4, these receptors participate both in host immune responses and in the pathogenesis of inflammatory diseases. Reduced disease severity in animal inflammatory models seen with LTB4 receptor antagonists and in mice with targeted deletion of BLT1 have revealed important roles for LTB4 and its receptors in regulating pathologic inflammation. (C) 2003 Elsevier Science Ltd. All rights reserved.