A Convenient Method for the Lewis Base-catalyzed Synthesis of α,β-Unsaturated Carboxylic Esters Using Trimethylsilylketene Ethyl Trimethylsilyl Acetal and Carbonyl Compounds
A Convenient Method for the Lewis Base-catalyzed Synthesis of α,β-Unsaturated Carboxylic Esters Using Trimethylsilylketene Ethyl Trimethylsilyl Acetal and Carbonyl Compounds
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DOI：
10.1246/cl.2008.704
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发表时间：
2008-05
影响因子：
1.6
通讯作者：
M. Michida;T. Mukaiyama
中科院分区：
文献类型：
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作者：
M. Michida;T. Mukaiyama
建立了在刘易斯碱催化剂如乙酸盐存在下，使用三甲基甲硅烷基β烯乙基三甲基甲硅烷基缩醛由各种羰基化合物合成α，β-不饱和羧酸酯的高度有用的方法。该方法在温和的条件下以高收率得到相应的酯，具有优异的E立体选择性。
A highly useful method for the synthesis of α,β-unsaturated carboxylic esters from various carbonyl compounds that uses trimethylsilylbetene ethyl trimethylsilyl acetal in the presence of a Lewis base catalyst such as acetate salts was established. This procedure gives the corresponding esters in high yields with excellent E stereoselectivity under mild conditions.