Cortical induction of c‐fos by intrastriatal endothelin‐1 is mediated via NMDA receptors
Cortical induction of c‐fos by intrastriatal endothelin‐1 is mediated via NMDA receptors
复制标题
纹状体内皮素-1 对 c-fos 的皮质诱导是通过 NMDA 受体介导的
DOI：
10.1097/00001756-199612200-00043
复制
发表时间：
1996
期刊：
影响因子：
1.7
通讯作者：
A. Morton
中科院分区：
文献类型：
--
作者：
A. Sullivan;D. Reynolds;K. Thomas;A. Morton
内皮素（ET）是一种有效的血管收缩剂，也被认为是一种神经调质。我们已经研究了ET-1在体内对神经元的作用，使用c-fos作为神经元活化的标志物。纹状体内注射ET-1可引起大鼠惊厥和滚桶运动，N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK-801可阻断ET-1引起的惊厥和滚桶运动，一氧化氮合酶（NOS）抑制剂Nω-硝基-L-精氨酸（L-NNA）可抑制ET-1引起的惊厥和滚桶运动。在与这些行为，c-fos mRNA的表达显着增加，被认为是在大脑皮层。这种增加被MK-801和L-NNA阻断。我们认为，ET-1调节皮层传入纹状体的活动，并通过NMDA受体依赖性机制引起癫痫发作。
ENDOTHELIN (ET) is a potent vasoconstrictor which has also been proposed to act as a neuromodulator. We have investigated the action of ET-1 on neurones in vivo, using c-fos as a marker of neuronal activation. Intrastriatal injection of ET-1 caused seizures and barrel rolling which were prevented by pretreatment with the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 and attenuated by the nitric-oxide synthase inhibitor Nω-nitro-L-arginine (L-NNA). In association with these behaviours, a dramatic increase in c-fos mRNA expression was seen in the cerebral cortex. This increase was blocked by both MK-801 and L-NNA. We suggest that ET-1 modulates the activity of cortical afferents to the striatum, and causes seizures via an NMDA receptor-dependent mechanism.
DOI：
10.1016/0013-4694(72)90177-0
发表时间：
1972-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
RACINE, RJ
通讯作者：
RACINE, RJ