Non-hormonal male contraception: A review and development of an Eppin based contraceptive.
Non-hormonal male contraception: A review and development of an Eppin based contraceptive.
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DOI：
10.1016/j.pharmthera.2015.11.004
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发表时间：
2016-01
影响因子：
13.5
通讯作者：
Hamil KG
中科院分区：
文献类型：
--
作者：
O'Rand MG;Silva EJ;Hamil KG
开发一种非荷尔蒙男性避孕药需要确定和确定适当的目标，并证明其在生殖中的重要作用。在这里，我们回顾了男性避孕靶点的发展和目前正在考虑的治疗药物。此外，还对Eppin作为避孕靶点的研究进展进行了综述。Eppin是人类精子表面的一种蛋白，在灵长类动物的生殖过程中具有重要的功能。Eppin被讨论为靶标开发的例子，在非人类灵长类动物中的测试，以及寻找模仿避孕抗体的小有机化合物；结合Eppin和阻止精子运动。尽管在非荷尔蒙男性避孕药成功之前还有许多障碍，但持续的坚持应该会产生一种适销对路的产品。
Developing a non-hormonal male contraceptive requires identifying and characterizing an appropriate target and demonstrating its essential role in reproduction. Here we review the development of male contraceptive targets and the current therapeutic agents under consideration. In addition, the development of EPPIN as a target for contraception is reviewed. EPPIN is a well characterized surface protein on human spermatozoa that has an essential function in primate reproduction. EPPIN is discussed as an example of target development, testing in non-human primates, and the search for small organic compounds that mimic contraceptive antibodies; binding EPPIN and blocking sperm motility. Although many hurdles remain before the success of a non-hormonal male contraceptive, continued persistence should yield a marketable product.