Effect of adenosine triphosphate on the accessory pathways.
Effect of adenosine triphosphate on the accessory pathways.
复制标题
三磷酸腺苷对旁路的影响。
作者：
B. Perrot;J. Clozel;G. Faivre
为了确定 Wolff-Parkinson-White 综合征 (WPW) 中顺行和逆行传导的部位，在 53 名心室预激患者的电生理学研究中注射了 40 mg 三磷酸腺苷 (ATP)。 40 例中旁路明显（第 1 组），13 例中旁路隐蔽（第 2 组）。第1组10例，顺行传导消失，预激特征消失。第 1 组的 7 名患者和第 2 组的 4 名患者中，旁路逆行传导延长或消失。这些作用是出乎意料的，因为 ATP 是一种拟副交感神经药物。 Kent有效不应期（ERP）与ATP的作用之间存在相关性。当药物不改变Kent束的顺行和逆行传导时，顺行旁路ERP始终小于230 ms。当 ATP 仅减少 Kent 束逆行传导时，顺行旁路 ERP 始终大于 280 ms。
To determine the site of the anterograde and retrograde conduction in the Wolff-Parkinson-White syndrome (WPW), 40 mg of adenosine triphosphate (ATP) was injected during electrophysiological studies in 53 patients with ventricular preexcitation. In 40 cases, the accessory pathway was evident (group 1) and in 13 cases it was concealed (group 2). In 10 cases in group 1, anterograde conduction was abolished with disappearance of the features of preexcitation. In 7 patients of group 1 and in 4 patients of group 2, retrograde conduction in the accessory pathway was prolonged or abolished. These effects were unexpected because ATP is a parasympathomimetic drug. There was a correlation between the Kent effective refractory period (ERP) and the action of ATP. When the drug did not change the anterograde and retrograde conduction in the Kent bundle, the anterograde accessory pathway ERP was always less than 230 ms. When ATP only decreased retrograde conduction in the Kent bundle, anterograde accessory pathway ERP was always more than 280 ms.