Smoking is not associated with nonalcoholic fatty liver disease.
Smoking is not associated with nonalcoholic fatty liver disease.
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DOI：
10.3748/wjg.v12.i32.5196
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发表时间：
2006-08
影响因子：
4.3
通讯作者：
N. Chavez-Tapia;J. Lizardi-Cervera;Oliver Pérez-Bautista;M. Ramos-Ostos;M. Uribe
中科院分区：
文献类型：
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作者：
N. Chavez-Tapia;J. Lizardi-Cervera;Oliver Pérez-Bautista;M. Ramos-Ostos;M. Uribe
目的分析吸烟与非酒精性脂肪性肝病（NAFLD）的关系。方法：这是一项健康人群的横断面研究，在墨西哥城一所大学医院的体检室进行。我们招募了933名受试者，368名当前吸烟者（病例）和565名从未吸烟的人（对照组）。对两组进行人口统计学、代谢和生化指标的测量。采用超声和代谢综合征ATP Ⅲ测定NAFLD。结果共纳入548例男性（205例病例和343例对照）和337例女性（114例病例和223例对照）。仅在高血压患病率方面观察到病例组和对照组之间的统计学差异（6.6% vs 11.3%，P < 0.05;病例组和对照组），高密度脂蛋白（1.00 ± 0.26 vs 1.06 ± 0.28 mmol/L，P < 0.005），甘油三酯（2.18 +/- 1.49 vs 1.84 +/- 1.1 mmol/L，P < 0.001）和红细胞沉降率（11.3 +/- 9.3 vs 13.5 +/- 11.9 mm/h，P < 0.001）。NAFLD（22.27%vs29.68%，P = NS）和代谢综合征（41.69%vs36.74%，P = NS）的患病率无差异。单因素分析显示吸烟不是NAFLD的危险因素（OR = 0.89，95% CI 0.65-1.21）。结论目前吸烟者与非吸烟者NAFLD患病率无差异，重度吸烟者（≥ 20包/年）NAFLD患病率无差异，提示吸烟与NAFLD无相关性。
AIM To analyze the relationship between smoking and nonalcoholic fatty liver disease (NAFLD). METHODS This is a cross-sectional study of a healthy population, carried out in a check-up unit of a university hospital in Mexico City. We enrolled 933 subjects, 368 current smokers (cases) and 565 persons who had never smoked (controls). Demographic, metabolic and biochemical variables were measured in the two groups. NAFLD was determined by ultrasound and metabolic syndrome according to ATPIII. RESULTS A total of 548 men (205 cases and 343 controls) and 337 women (114 cases and 223 controls) were included in the analysis. Statistical differences between cases and controls were observed only in high blood pressure prevalence (6.6% vs 11.3%, P < 0.05; cases and controls respectively), high-density lipoproteins (1.00 +/- 0.26 vs 1.06 +/- 0.28 mmol/L, P < 0.005), triglycerides (2.18 +/- 1.49 vs 1.84 +/- 1.1 mmol/L, P < 0.001), and erythrocyte sedimentation rate (11.3 +/- 9.3 vs 13.5 +/- 11.9 mm/h, P < 0.001). No differences were observed in the prevalence of NAFLD (22.27% vs 29.68%, P = NS) and metabolic syndrome (41.69% vs 36.74%, P = NS). Univariate analysis showed that smoking was not a risk factor for NAFLD (OR = 0.89, 95% CI 0.65-1.21). CONCLUSION No differences in NAFLD prevalence were observed between current smokers and nonsmokers, and furthermore, no differences were observed in heavy smokers (more than 20 packs/year), indicating that there is no relationship between smoking and NAFLD.