A twenty-five-year follow-up study of women exposed to diethylstilbestrol during pregnancy.
A twenty-five-year follow-up study of women exposed to diethylstilbestrol during pregnancy.
复制标题
对怀孕期间接触己烯雌酚的妇女进行的二十五年跟踪研究。
DOI：
--
复制
发表时间：
1978
影响因子：
158.5
通讯作者：
A. Herbst
中科院分区：
文献类型：
--
作者：
M. Bibbo;William M. Haensxel;G. Wied;M. M. Hubby;A. Herbst
为了评估己烯雌酚的长期效果，我们对怀孕期间服用该药的693名母亲和668名未服用该药的母亲进行了一项健康调查。这些女性在1951-52年间参与了一项评估该药物的研究。暴露者693人，乳腺癌32人(4.6%)；未暴露者668人，乳腺癌21人(3.1%)，但差异无统计学意义(P=0.16)。在其他任何一类疾病中，两组之间没有统计上的显著差异。将两组患者的乳腺癌发生率与康涅狄格州肿瘤登记处1963-65年的数据进行比较。与登记数据相比，在50岁以上的暴露组和非暴露组中，乳腺癌的发病率都显著(P<0.01)高。这一增加的原因尚不清楚，但不能排除与参与最初临床研究的母亲的选择有关的影响。
To assess the long-term effects of diethylstilbestrol we conducted a health survey among 693 mothers who had taken the drug during pregnancy and a comparable group of 668 who had not. These women had participated in a study during 1951-52 to evaluate the drug. There were 32 (4.6 per cent) breast cancers among the 693 exposed and 21 (3.1 per cent) among the 668 unexposed, but the difference was not statistically significant (P = 0.16). No statistically significant differences occurred between the groups in any of the other categories of disease. The occurrence of breast cancer in both groups was compared to the Connecticut State Tumor Registry for 1963-65. Compared to the registry data, a significantly (P less than 0.01) higher incidence of breast cancer occurred in both the exposed and unexposed groups at ages over 50. The reason for this increase is not known, but effects linked to the selection of mothers participating in the original clinical study cannot be excluded.