Monocyte chemotactic protein-1 level in the aqueous humour as a prognostic factor for the outcome of trabeculectomy
Monocyte chemotactic protein-1 level in the aqueous humour as a prognostic factor for the outcome of trabeculectomy
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DOI：
10.1111/ceo.12204
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发表时间：
2014-05-01
影响因子：
4
通讯作者：
Tanihara, Hidenobu
中科院分区：
文献类型：
--
作者：
Inoue, Toshihiro;Kawaji, Takahiro;Tanihara, Hidenobu
本研究的目的是阐明眼房水单核细胞趋化蛋白-1水平对有晶状体眼青光眼小梁切除术疗效的影响。设计回顾性研究。对象53例开角型青光眼患者。方法在小梁切除术时，在任何切口之前收集房水样品。然后通过免疫测定法测定单核细胞趋化蛋白-1水平。采用考克斯比例风险检验分析与小梁切除术失败相关的临床因素。随后，通过Kaplan-Meier分析计算成功概率，并通过对数秩检验分析累积成功概率。主要结果测量成功的可能性。结果30例有晶状体眼青光眼和23例人工晶状体眼青光眼患者的房水中单核细胞趋化蛋白-1的平均水平分别为1165.2和2152.9pg/mL，差异有统计学意义（P
Background The aim of this study was to elucidate the effects of the aqueous humour monocyte chemotactic protein-1 level on the surgical outcome of trabeculectomy in cases of phakic glaucoma. Design Retrospective study. Participants Fifty-three cases of open-angle glaucoma. Methods At the time of trabeculectomy, aqueous humour samples were collected before any incisions were made. The monocyte chemotactic protein-1 level was then determined by immunoassay. The Cox proportional hazards test was used to analyse the clinical factors related to failure of trabeculectomy. Subsequently, the success probability was calculated by Kaplan-Meier analysis and cumulative success probabilities were analysed by the log-rank test. Main Outcome Measures Probability of success. Results In 30 phakic glaucoma and 23 pseudophakic glaucoma cases, the mean monocyte chemotactic protein-1 levels in aqueous humour were 1165.2 and 2152.9pg/mL, respectively; the difference was statistically significant (P