[Osteocalcin (or bone gla-protein), a new biological marker for studying bone pathology].
[Osteocalcin (or bone gla-protein), a new biological marker for studying bone pathology].
复制标题
[骨钙素（或骨gla-蛋白），一种用于研究骨病理学的新生物标记物]。
作者：
P. Delmas;B. Demiaux;L. Malaval;M. Chapuy;P. Meunier
骨钙素，又称骨钙素蛋白，是一种由成骨细胞特异性合成的骨基质蛋白。它在血液中循环，可以通过放射免疫方法进行检测。我们测量了169名成人对照组和161名不同播散性或局限性骨病患者的血清骨钙素水平。正常浓度为6.2 +/- 0.2 ng/ml，随着年龄的增长而显著增加。血清骨钙素水平在肾性骨营养不良（114 +/- 23 ng/ml）中显著增加，在原发性甲状旁腺功能亢进（15.9 +/- 2.8 ng/ml）和佩吉特病（11.4 +/- 0.9 ng/ml）中程度较轻，所有疾病的特征都是骨转换增加。在骨软化症中也遇到高水平（9.7 +/- 0.9 ng/ml）。相反，长期皮质类固醇治疗的患者血清骨钙素水平显著降低（4.3 +/- 0.5 ng/ml）;在治疗中的骨骨髓瘤和骨转移患者血清骨钙素水平保持正常。最后，骨钙素在骨质疏松症患者中是正常的，但其水平反映了髂骨活检评估的骨转换。因此，循环骨钙素是骨转换的第一个特异性和敏感性标志物。血清骨钙素的测量可以在不进行活检的情况下评价成骨细胞的骨形成，并应提供药物作用于骨形成过程的有效性的信息。
Osteocalcin, also called bone gla-protein, is a bone matrix protein synthetized specifically by osteoblasts. It circulates in blood where it can be assayed by the radioimmune method. We measured osteocalcin serum levels in 169 adult controls and 161 patients with different disseminated or localized bone diseases. The normal concentration of 6.2 +/- 0.2 ng/ml increases significantly with age. Serum osteocalcin levels are considerably increased in renal osteodystrophy (114 +/- 23 ng/ml) and to a lesser degree in primary hyperparathyroidism (15.9 +/- 2.8 ng/ml) and Paget's disease (11.4 +/- 0.9 ng/ml), all diseases characterized by increased bone turnover. High levels are also encountered in osteomalacia (9.7 +/- 0.9 ng/ml). Conversely, serum osteocalcin levels are significantly decreased in patients under long-term corticosteroid therapy (4.3 +/- 0.5 ng/ml); they remain normal in patients with bone myeloma and bone metastases under treatment. Finally, osteocalcin is normal in patients with osteoporosis, but its level reflects that of bone turnover as evaluated by iliac bone biopsy. The circulating osteocalcin therefore is the first specific and sensitive marker for bone turnover. Serum osteocalcin measurements make it possible to evaluate the osteoblastic bone formation without biopsy and should provide information on the effectiveness of drugs acting on the bone-forming process.