Nickel-catalyzed coupling of R2P(O)Me (R = aryl or alkoxy) with (hetero)arylmethyl alcohols.
Nickel-catalyzed coupling of R2P(O)Me (R = aryl or alkoxy) with (hetero)arylmethyl alcohols.
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DOI：
10.1039/d1ob00086a
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发表时间：
2021-02
影响因子：
3.2
通讯作者：
Wei‐ze Li;Zhong‐Xia Wang
中科院分区：
文献类型：
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作者：
Wei‐ze Li;Zhong‐Xia Wang
在镍催化下，甲基二芳基氧化膦与（杂）芳基甲醇发生α-烷基化反应。各种芳基甲基和杂芳基甲基醇可用于该转化。一系列甲基二芳基氧化膦的烷基化反应产率为30-90%。甲基二芳基氧化膦或芳基甲基醇的芳环上的官能团包括OMe、NMe 2、SMe、CF 3、Cl和F基团是可以容许的。该条件也适用于甲基膦酸二烷基酯的α-烷基化反应。
α-Alkylation of methyldiarylphosphine oxides with (hetero)arylmethyl alcohols was performed under nickel catalysis. Various arylmethyl and heteroarylmethyl alcohols can be used in this transformation. A series of methyldiarylphosphine oxides were alkylated with 30-90% yields. Functional groups on the aromatic rings of methyldiarylphosphine oxides or arylmethyl alcohols including OMe, NMe2, SMe, CF3, Cl, and F groups can be tolerated. The conditions are also suitable for the α-alkylation reaction of dialkyl methylphosphonates.