Production of type VI collagen by human macrophages: A new dimension in macrophage functional heterogeneity
Production of type VI collagen by human macrophages: A new dimension in macrophage functional heterogeneity
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DOI：
10.4049/jimmunol.180.8.5707
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发表时间：
2008-04-15
影响因子：
4.4
通讯作者：
Lorkowski, Stefan
中科院分区：
文献类型：
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作者：
Schnoor, Michael;Cullen, Paul;Lorkowski, Stefan
来自人类血液单核细胞的巨噬细胞执行许多与组织损伤和修复相关的任务。巨噬细胞对细胞外基质的主要作用被认为本质上是破坏性的，因为巨噬细胞分泌金属蛋白酶并摄取外来物质，作为伤口愈合和其他病理状况中发生的重塑过程的一部分。然而，巨噬细胞也有助于细胞外基质，从而通过诱导其他细胞增殖和释放基质成分来间接地促进组织稳定，以及通过分泌细胞外基质的成分（如纤连蛋白和 VIII 型胶原）来直接地稳定组织，正如我们最近所证明的那样。我们现在报道单核细胞和巨噬细胞几乎表达所有已知的胶原蛋白和胶原蛋白相关的 mRNA。此外，巨噬细胞大量分泌 VI 型胶原蛋白，具体取决于其激活模式、分化阶段和细胞密度。巨噬细胞分泌的 VI 型胶原蛋白的主要功能似乎是调节细胞-细胞和细胞-基质相互作用。我们认为，VI 型胶原蛋白的产生是一种非破坏性、基质保守型巨噬细胞表型的标志，可以深刻影响体内的生理和病理生理条件。
Macrophages derived from human blood monocytes perform many tasks related to tissue injury and repair. The main effect of macrophages on the extracellular matrix is considered to be destructive in nature, because macrophages secrete metalloproteinases and ingest foreign material as part of the remodeling process that occurs in wound healing and other pathological conditions. However, macrophages also contribute to the extracellular matrix and hence to tissue stabilization both indirectly, by inducing other cells to proliferate and to release matrix components, and directly, by secreting components of the extracellular matrix such as fibronectin and type VIII collagen, as we have recently shown. We now report that monocytes and macrophages express virtually all known collagen and collagen-related mRNAs. Furthermore, macrophages secrete type VI collagen protein abundantly, depending upon their mode of activation, stage of differentiation, and cell density. The primary function of type VI collagen secreted by macrophages appears to be modulation of cell-cell and cell-matrix interactions. We suggest that the production of type VI collagen is a marker for a nondestructive, matrix-conserving macrophage phenotype that could profoundly influence physiological and pathophysiological conditions in vivo.