A prognostic analysis of 895 cases of stage III colon cancer in different colon subsites
A prognostic analysis of 895 cases of stage III colon cancer in different colon subsites
复制标题
895例不同结肠亚部位Ⅲ期结肠癌预后分析
DOI：
10.1007/s00384-015-2273-z
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发表时间：
2015-09-01
影响因子：
2.8
通讯作者：
Zeng, Shan
中科院分区：
文献类型：
--
作者：
Zhang, Yan;Ma, Junli;Zeng, Shan
PurposeStage III colon cancer is currently treated as an entity with a unified therapeutic principle. The aim of the retrospective study is to explore the clinicopathological characteristics and outcomes of site-specific stage III colon cancers and the influences of tumor location on prognosis.MethodsEight hundred ninety-five patients with stage III colon cancer treated with radical operation and subsequent adjuvant chemotherapy (5-fluorouracil/oxaliplatin) were divided into seven groups according to colon segment (cecum, ascending colon, hepatic flexure, transverse colon, splenic flexure, descending colon, and sigmoid colon). Expression of excision repair cross-complementing group 1 (ERCC1) and thymidylate synthase (TS) was examined by immunohistochemistry. We assessed if differences exist in patient characteristics and clinic outcomes between the seven groups.ResultsThere were significant differences in tumor differentiation (P< 0.001), T stage (P< 0.001), N stage (P< 0.001), American Joint Committee on Cancer (AJCC) tumor–node–metastasis (TNM) stage (P< 0.001), metachronous liver metastasis (P< 0.001), metachronous lung metastasis (P< 0.001), and ERCCI expression (P< 0.001) between the seven groups. Both 5-year recurrence-free survival (RFS) and 5-year overall survival (OS) exhibited significant differences (bothP< 0.001) with survival gradually decreasing from cecum to sigmoid colon. Cox regression analyses identified that tumor location was an independent prognostic factor for RFS and OS.ConclusionsStage III colon cancer located proximally carried a poorer survival than that located distally. Different efficacies of FOLFOX adjuvant chemotherapy may be an important factor affecting survival of site-specific stage III colon cancers.
