Biological effects of Mammalian translationally controlled tumor protein (TCTP) on cell death, proliferation, and tumorigenesis.
Biological effects of Mammalian translationally controlled tumor protein (TCTP) on cell death, proliferation, and tumorigenesis.
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DOI：
10.1155/2012/204960
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发表时间：
2012
影响因子：
3
通讯作者：
Ichikawa S
中科院分区：
文献类型：
--
作者：
Nagano-Ito M;Ichikawa S
翻译控制肿瘤蛋白（TCTP）是一种高度保守的蛋白质，存在于真核生物、动植物界甚至酵母中。哺乳动物 TCTP 在各种组织和细胞类型中普遍表达。 TCTP是一种多功能蛋白，在许多细胞生理事件中发挥重要作用，例如免疫反应、细胞增殖、致瘤性和细胞死亡（包括细胞凋亡）。最近，TCTP 作为一种抗凋亡蛋白的鉴定引起了该领域许多研究人员的兴趣。然而，抗凋亡活性的机制尚未完全解决，TCTP 可能会抑制其他类型的细胞死亡。细胞死亡（包括细胞凋亡）与增殖和肿瘤发生密切相关。在此背景下，我们回顾了有关 TCTP 在细胞死亡、增殖和肿瘤发生中的作用的最新发现，并讨论了其机制。
Translationally controlled tumor protein (TCTP) is a highly conserved protein found in eukaryotes, across animal and plant kingdoms and even in yeast. Mammalian TCTP is ubiquitously expressed in various tissues and cell types. TCTP is a multifunctional protein which plays important roles in a number of cell physiological events, such as immune responses, cell proliferation, tumorigenicity, and cell death, including apoptosis. Recent identification of TCTP as an antiapoptotic protein has attracted interest of many researchers in the field. The mechanism of antiapoptotic activity, however, has not been solved completely, and TCTP might inhibit other types of cell death. Cell death (including apoptosis) is closely linked to proliferation and tumorigenesis. In this context, we review recent findings regarding the role of TCTP in cell death, proliferation, and tumorigenesis and discuss the mechanisms.