Persistent candidemia despite appropriate fungal therapy: First case of Candida auris from the United Arab Emirates
Persistent candidemia despite appropriate fungal therapy: First case of Candida auris from the United Arab Emirates
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DOI：
10.1016/j.ijid.2018.02.005
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发表时间：
2018-05-01
影响因子：
8.4
通讯作者：
Mirza, Imran
中科院分区：
文献类型：
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作者：
Alatoom, Adnan;Sartawi, Mohammad;Mirza, Imran
在该病例中，我们报告了一名患有多种慢性病且长期入住重症监护病房 (ICU) 的老年患者，尽管接受了抗真菌治疗，但血液中仍出现耳念珠菌 (C. auris) 复发。使用传统的自动识别系统将耳念珠菌误识别为血念珠菌，导致诊断延迟。该分离株对不同抗真菌药物的最低抑菌浓度 (MIC) 有所增加，并在患者死亡前持续存在于患者的血液中。这是阿拉伯联合酋长国（阿联酋）报告的第一例耳念珠菌病例；实验室应了解这种念珠菌属，并应确认疑似病例，因为它是一种新兴的多重耐药性和卫生保健相关的念珠菌。 (C) 2018 作者。由爱思唯尔有限公司代表国际传染病学会出版。
In this case, we report an elderly patient with multiple chronic conditions and prolonged intensive care unit (ICU) stays who had recurrent Candida auris (C. auris) in blood despite antifungal therapy. C. auris was misidentified using conventional automated identification system as Candida haemulonii resulting in delayed diagnosis. The isolate showed increasing minimum inhibitory concentrations (MICs) to different antifungal drugs and persisted in the patient's blood before the patient deceased. This is the first case of C. auris reported from the United Arab Emirates (UAE); laboratories should be aware of this Candida species and should confirm suspected cases since it is an emerging multi-drug resistant and health-care associated Candida. (C) 2018 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.