Distribution and clearance of circulating endotoxin.
Distribution and clearance of circulating endotoxin.
复制标题
循环内毒素的分布和清除。
DOI：
10.1172/jci104698
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发表时间：
1963
期刊：
影响因子：
--
通讯作者：
J. G. Palmer
中科院分区：
文献类型：
--
作者：
W. Herring;J. Herion;R. Walker;J. G. Palmer
为了阐明内毒素的作用机制，对新西兰大白兔体内注射内毒素的分布和清除进行了研究，其中一些动物通过连续(5天)注射内毒素(大肠杆菌脂多糖)而变得耐受，其余动物则不耐受。小剂量铬标记内毒素的血液和血浆清除在耐受组比不耐受组更快。两组在注射后10分钟内几乎完成清除。循环内毒素在非耐受动物和耐受动物的血浆和血小板之间均有分布。在白细胞中发现了极少量的内毒素，这被认为是污染血小板的结果。
To elucidate the mechanisms of endotoxin action the distribution and clearance of injected endotoxin were studied in New Zealand white rabbits; some animals were rendered tolerant through successive (5 days) doses of endotoxin (E. coli lipopolysaccharide) and the remainder were nontolerant. Blood and plasma clearance of small doses of chromium-labeled endotoxin was more rapid in tolerant than in nontolerant rabbits. In both groups clearance was nearly complete within 10 minutes after injection. Circulating endotoxin was distributed between plasma and platelets in both non- and tolerant animals. A minimal amount of endotoxin was found in leukocytes by this was believed the result of contaminating platelets.