Ontogeny of methamphetamine-induced and cocaine-induced one-trial behavioral sensitization in preweanling and adolescent rats.
Ontogeny of methamphetamine-induced and cocaine-induced one-trial behavioral sensitization in preweanling and adolescent rats.
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DOI：
10.1097/fbp.0b013e32835651c9
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发表时间：
2012-08
影响因子：
1.6
通讯作者：
McDougall SA
中科院分区：
文献类型：
--
作者：
Kozanian OO;Gutierrez A;Mohd-Yusof A;McDougall SA
尚未确定精神兴奋剂诱导的一次性行为敏化的个体发育特征。本研究的目的是系统地评估个体发育的甲基苯丙胺和可卡因诱导的行为敏化在断奶前和青少年时期。为此，在断奶前（PD 12、PD 16或PD 20）、青春期前（PD 24）或青春期（PD 34）期间，在活动室或饲养笼中给大鼠注射甲基苯丙胺、可卡因或生理盐水。一天后，用相同的精神兴奋剂激发大鼠，并在活动室中测量运动。结果表明，甲基苯丙胺对PD 13和PD 17产生一次性运动敏化;而可卡因诱导的行为敏化仅在PD 21上明显。断奶前大鼠的致敏反应不受环境条件的影响。有趣的是，青春期前和青春期大鼠没有表现出运动敏化。后一个结果与过去的研究基本一致，表明青春期中后期的大鼠不会表现出可卡因诱导的一次性行为敏化。目前的研究结果表明，甲基苯丙胺，以及可卡因，可以产生一个审判的上下文无关的行为敏化在早期个体发育，但敏化反应只在一个狭窄的发展窗口是明显的。
The ontogenetic profile of psychostimulant-induced one-trial behavioral sensitization has not been determined. The purpose of this study was to systematically assess the ontogeny of methamphetamine- and cocaine-induced behavioral sensitization across the preweanling and adolescent periods. To this end, rats were injected with methamphetamine, cocaine, or saline in either an activity chamber or home cage during the preweanling (PD 12, PD 16, or PD 20), preadolescent (PD 24), or adolescent (PD 34) periods. One day later, rats were challenged with the same psychostimulant and locomotion was measured in an activity chamber. Results showed that methamphetamine produced one-trial locomotor sensitization on PD 13 and PD 17; whereas, cocaine-induced behavioral sensitization was only evident on PD 21. The sensitized responding of preweanling rats was not influenced by environmental context. Interestingly, preadolescent and adolescent rats did not exhibit locomotor sensitization. The latter result is generally consistent with past studies showing that rats from the middle and late adolescent periods do not exhibit cocaine-induced one-trial behavioral sensitization. The present results show that methamphetamine, as well as cocaine, can produce one-trial context-independent behavioral sensitization during early ontogeny, but sensitized responding is only apparent within a narrow developmental window.