Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: A meta-analysis
Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: A meta-analysis
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DOI：
10.1016/j.jad.2005.05.014
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发表时间：
2005-09-01
影响因子：
6.6
通讯作者：
Bremner, JD
中科院分区：
文献类型：
--
作者：
Kitayama, N;Vaccarino, V;Bremner, JD
背景：动物研究表明，海马体是参与学习和记忆的大脑区域，对压力很敏感。尽管一些 MRI 研究显示患有慢性 PTSD 的成年人的海马体积较小，但其他研究并未显示出与对照组的显着差异。这些研究的特点是样本量较小，这可能会限制显示显着差异的能力。因此，我们对所有这些研究进行了荟萃分析研究，以阐明海马结构变化在 PTSD 受试者中的作用。方法：荟萃分析中纳入了 9 项研究，总共 133 名患有慢性 PTSD 的成年受试者、148 名健康对照和 53 名受创伤的对照。结果：与健康对照和创伤对照相比，慢性 PTSD 成年受试者的左右海马体积均明显较小。结论：这些发现与患有慢性创伤后应激障碍的成年受试者的海马体积较小是一致的。 (c) 2005 Elsevier B.V. 保留所有权利。
Background: Studies in animals showed that the hippocampus, a brain area involved in learning and memory, is sensitive to stress. Although several MRI studies showed smaller hippocampal volume in adults with chronic PTSD, others did not show significant differences from controls. These studies are typified by small sample sizes which may limit the ability to show significant differences. We therefore performed a meta-analytic study of all of these studies to clarify the role of hippocampal structural changes in subjects with PTSD.Methods: Nine studies with a total of 133 adult subjects with chronic PTSD, 148 healthy controls, and 53 traumatized controls were included in the meta-analysis.Results: There was significantly smaller volume in both right and left hippocampi in adult subjects with chronic PTSD in comparison with both healthy controls and traumatized controls.Conclusion: These findings are consistent with smaller hippocampal volume in adult subjects with chronic PTSD. (c) 2005 Elsevier B.V. All rights reserved.