Vitellogenin as a biomarker for environmental estrogens
Vitellogenin as a biomarker for environmental estrogens
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DOI：
10.2166/wst.2000.0546
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发表时间：
2000-10
影响因子：
2.7
通讯作者：
Paul D. Jones;W. Coen;L. Tremblay;J. Giesy
中科院分区：
文献类型：
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作者：
Paul D. Jones;W. Coen;L. Tremblay;J. Giesy
最近的兴趣主要集中在环境中的“异种雌激素”上。这些化学品有可能扰乱野生动物的激素功能，因此开发了监测这些化合物排放影响的技术，特别是在水生环境中。鱼和其他脊椎动物血浆中卵黄前体蛋白、卵黄蛋白原（Vtg）浓度的增加已被确定为具有雌激素样性质的化学品暴露及其影响的潜在有用生物标志物。在这里，我们回顾了Vtg生产的机制，Vtg的分析方法，以及测量Vtg生产的化学品或污水暴露的研究。这些研究表明，Vtg的产生可能是一个有用的生物标志物暴露于雌激素化学品，但需要更深入地了解这些化学品的作用机制。在鲤科鱼类的生殖终点更敏感，以确保对外源性雌激素比Vtg诱导。这些观察结果表明，Vtg诱导作为暴露于外源性雌激素的生物标志物，而不是不良反应的预测因子更有用。
Much recent interest has focused on “xenoestrogens” in the environment. The potential for these chemicals to disrupt hormonal function in wildlife has led to the development of techniques to monitor the effects of discharges of these compounds particularly in aquatic environments. Increases in the concentration of the egg yolk precursor protein, vitellogenin (Vtg), in the plasma of fish and other vertebrates have been identified as a potentially useful biomarker of exposure to and the effects of chemicals with estrogen like properties. Here, we review the mechanisms underlying Vtg production, methods for the analysis of Vtg, and studies that have measured Vtg production in response to chemical or effluent exposure. These studies indicate that the production of Vtg may be a useful biomarker of exposure to estrogenic chemicals but that a greater understanding of the mechanism of action of these chemicals is required. In cyprinid fishes reproductive endpoints are more sensitive to exposureto xenoestrogens than Vtg induction. These observations indicate that Vtg induction is of more use as a biomarker of exposure to xenoestrogens rather than a predictor of adverse effects.