BMP inhibition enhances axonal growth and functional recovery after spinal cord injury
BMP inhibition enhances axonal growth and functional recovery after spinal cord injury
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DOI：
10.1111/j.1471-4159.2008.05251.x
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发表时间：
2008-05-01
影响因子：
4.7
通讯作者：
Yamashita, Toshihide
中科院分区：
文献类型：
--
作者：
Matsuura, Iichiro;Taniguchi, Junko;Yamashita, Toshihide
骨形态发生蛋白（BMP）是一种多功能的生长因子，属于转化生长因子β超家族。BMP调节胚胎发育和器官发生的几个关键方面。骨形成蛋白在受损的成年中枢神经系统中的重新出现表明它们参与了病变的发病机制。在这里，我们证明骨形态发生蛋白是有效的抑制剂轴突再生的成年脊髓。BMP-2/4在脊髓挫伤后损伤部位周围的少突胶质细胞和星形胶质细胞中表达增加。鞘内注射noggin -一种可溶性BMP拮抗剂-可增强运动活性，并揭示脊髓挫伤后皮质脊髓束的显著再生。因此，BMP在抑制轴突再生和限制CNS损伤后的功能恢复中起作用。
Bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the transforming growth factor-beta superfamily. BMPs regulate several crucial aspects of embryonic development and organogenesis. The reemergence of BMPs in the injured adult CNS suggests their involvement in the pathogenesis of the lesion. Here, we demonstrate that BMPs are potent inhibitors of axonal regeneration in the adult spinal cord. The expression of BMP-2/4 is elevated in oligodendrocytes and astrocytes around the injury site following spinal cord contusion. Intrathecal administration of noggin - a soluble BMP antagonist-leads to enhanced locomotor activity and reveals significant regrowth of the corticospinal tract after spinal cord contusion. Thus, BMPs play a role in inhibiting axonal regeneration and limiting functional recovery following injury to the CNS.