Leucine metabolism in thyrotoxicosis: plasma aminogram and 3-methylhistidine excretion before and after treatment.
Leucine metabolism in thyrotoxicosis: plasma aminogram and 3-methylhistidine excretion before and after treatment.
复制标题
甲状腺毒症中的亮氨酸代谢：治疗前后的血浆氨基酸图和 3-甲基组氨酸排泄。
DOI：
10.1016/0026-0495(85)90104-0
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Adibi,SA
中科院分区：
文献类型：
--
作者：
Hagg,SA;Adibi,SA
以往的研究表明，甲状腺功能亢进症患者的蛋白质代谢增加，肌肉代谢改变。本实验观察了甲亢患者治疗前后蛋白质和亮氨酸代谢的变化。当被限制在代谢病房时，患者的每日热量摄入是基于静息能量消耗和16小时轻度体力活动的津贴。我们发现治疗前后血浆氨基酸谱和尿3-甲基组氨酸排泄（蛋白质代谢指标）无显著差异。另一方面，甲状腺功能亢进症似乎增加内源性亮氨酸的氧化，营业额和血浆清除率。然而，只有亮氨酸氧化率增加60%才具有统计学意义。我们的结论是，尽管增加cataline，支链氨基酸的基础水平维持在甲亢患者的血浆中消耗的饮食，以补偿他们的高代谢状态。
Previous studies have suggested increased protein catabolism and altered muscle metabolism in hyperthyroid patients. In this experiment we investigated parameters of protein and leucine metabolism before and after treatment of hyperthyroidism. While confined in a metabolic ward, patients' daily caloric intake was based on the resting energy expenditure and an allowance for 16 hours of light physical activity. We found no significant difference in plasma aminogram and urinary 3-methylhistidine excretion (an index of protein catabolism) before and after treatment. On the other hand, hyperthyroidism appeared to increase the rates of oxidation, turnover, and plasma clearance of endogenous leucine. However, only the 60% increase in the rate of leucine oxidation was statistically significant. We conclude that in spite of increased catabolism, basal levels of branched-chain amino acids are well maintained in plasma of hyperthyroid patients consuming a diet that compensates for their hypermetabolic state.