Postherpetic neuralgia, diabetic neuropathy, and trigeminal neuralgia - Chronic peripheral neuropathic pain in 58,480 rural Italian primary care patients.
Postherpetic neuralgia, diabetic neuropathy, and trigeminal neuralgia - Chronic peripheral neuropathic pain in 58,480 rural Italian primary care patients.
复制标题
DOI：
10.4103/2249-4863.214980
复制
发表时间：
2017-01-01
影响因子：
1.4
通讯作者：
Cambielli, Marco
中科院分区：
文献类型：
--
作者：
Buono, Nicola;Thulesius, Hans;Cambielli, Marco
引言：慢性周围神经性疼痛（CPNP）是由于周围神经系统疾病或损伤引起的一种疾病，但其患病率在意大利初级保健中尚不清楚。目的：本研究的目的是评估北方意大利农村初级保健地区CPNP的患病率。材料和方法：在北方意大利的一个农村地区进行了一项多中心审计研究，113名参与的全科医生（GP）看到58，3个月内480例>18岁的患者。对于因任何原因参加全科医生手术并有神经性疼痛（NP）症状的患者，给予NP诊断问卷“Doubletree Neuropathique en 4 Questions”（DN 4），并在视觉模拟量表（VAS）上记录他们的疼痛水平。448例患者通过DN4评分≥4和VAS疼痛评分≥40 mm持续>6个月以及临床诊断确定慢性NP。58，480名患者中有254名女性和194名男性，患病率为0.77%。179例患者糖尿病神经病变142例（0.31%）有带状疱疹后遗痛者占0.24%，三叉神经痛27例（0.07%）伤后NP发生率为0.05%，神经卡压引起的NP占0.05%，全身性疾病引起的NP占0.02%，（0.04%）有不明病因的NP。在北方意大利农村地区的初级保健就诊者中，CPNP的患病率为0.77%。糖尿病神经病变（0.31%）和带状疱疹后疼痛（0.24%）是NP最常见的两个亚组，其次是三叉神经痛（0.07%）。
INTRODUCTION: Chronic peripheral neuropathic pain (CPNP) is a condition due to peripheral nervous system diseases or injury, but its prevalence is unknown in Italian primary care.AIM: The aim of this study is to assess the prevalence of CPNP in a rural primary care area in Northern Italy.MATERIALS AND METHODS: A multicenter audit study was carried out in a rural area in Northern Italy with 113 participating general practitioners (GPs) seeing 58,480 patients >18 years during 3 months. Patients who for any reason attended GPs' surgeries and had symptoms suggestive of neuropathic pain (NP) were given the NP diagnostic questionnaire "Douleur Neuropathique en 4 Questions" (DN4) and recorded their pain level on a visual analog scale (VAS).RESULTS: Chronic NP was established by a DN4 score of ≥4 and a VAS pain score of ≥40 mm for >6 months together with a clinical diagnosis in 448 (254 women and 194 men) out of 58,480 patients giving a prevalence of 0.77%. 179 patients (0.31%) had diabetes neuropathy, 142 (0.24%) had postherpetic pain, 41 (0.07%) had trigeminal neuralgia, 27 (0.05%) had NP postinjury, 27 (0.05%) had NP caused by nerve entrapments, 11 (0.02%) had NP triggered by systemic diseases, and 21 (0.04%) had NP of unknown etiology.CONCLUSIONS: The prevalence of CPNP in this population of primary care attenders in a rural area in Northern Italy was 0.77%. Diabetes neuropathy (0.31%) and postherpetic pain (0.24%) were the two most common subgroups of NP, followed by trigeminal neuralgia (0.07%).