TRIM proteins in hepatocellular carcinoma.
TRIM proteins in hepatocellular carcinoma.
复制标题
肝细胞癌中的 TRIM 蛋白
DOI：
10.1186/s12929-022-00854-7
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发表时间：
2022-09-13
影响因子：
11
通讯作者：
Zhang, Bixiang
中科院分区：
文献类型：
--
作者：
Lu, Kan;Pan, Yonglong;Huang, Zhao;Liang, Huifang;Ding, Ze-Yang;Zhang, Bixiang
The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain. Generally, TRIM proteins function as E3 ligases to facilitate specific proteasomal degradation of target proteins. In addition, E3 ligase independent functions of TRIM protein were also reported. In hepatocellular carcinoma, expressions of TRIM proteins are both regulated by genetic and epigenetic mechanisms. TRIM proteins regulate multiple biological activities and signaling cascades. And TRIM proteins influence hallmarks of HCC. This review systematically demonstrates the versatile roles of TRIM proteins in HCC and helps us better understand the molecular mechanism of the development and progression of HCC.
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影响因子：
5
作者：
Chung YL;Wu ML
通讯作者：
Wu ML
临时细胞性白血病蛋白的缺乏促进了小鼠肝炎相关的肝癌发生。
影响因子：
3.7
作者：
Herzer K;Carbow A;Sydor S;Sowa JP;Biesterfeld S;Hofmann TG;Galle PR;Gerken G;Canbay A
通讯作者：
Canbay A
DOI：
10.1016/j.clinre.2016.09.010
发表时间：
2017-03-01
影响因子：
2.7
作者：
Chen, Yue;Li, Liang;Xu, Geliang
通讯作者：
Xu, Geliang
影响因子：
8.4
作者：
Chan, JYH;Chin, W;Johnson, PJ
通讯作者：
Johnson, PJ
影响因子：
3.3
作者：
Bu N;Dong Z;Zhang L;Zhu W;Wei F;Zheng S
通讯作者：
Zheng S