Classical and Paradoxical Effects of TNF-α on Bone Homeostasis.
Classical and Paradoxical Effects of TNF-α on Bone Homeostasis.
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DOI：
10.3389/fimmu.2014.00048
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发表时间：
2014
影响因子：
7.3
通讯作者：
Miossec P
中科院分区：
文献类型：
--
作者：
Osta B;Benedetti G;Miossec P
肿瘤坏死因子-α（TNF-α）在几种慢性免疫性和炎性关节疾病的骨稳态调节中起重要作用，其中抑制TNF可导致显著的临床改善。然而，肿瘤坏死因子激活的途径和机制参与骨重建仍不清楚。目前，TNF-α被认为是成骨细胞分化的抑制剂和破骨细胞生成的激活剂。最近相互矛盾的研究结果表明，TNF-α也可以激活成骨细胞生成。TNF-α在骨稳态中的矛盾作用似乎取决于所用细胞类型的浓度和分化状态以及暴露时间。本文综述了TNF-α在离体细胞、全骨和全身水平上调节骨稳态的最新研究结果。此外，在炎性关节疾病（包括类风湿性关节炎和强直性脊柱炎，分别与骨破坏和异位钙化基质形成相关）中观察到TNF-α参与骨重建失衡。这两种疾病都与全身/脊椎骨质疏松症有关。
Tumor necrosis factor-α (TNF-α) plays an essential role in the regulation of bone homeostasis in several chronic immune and inflammatory joint diseases, where inhibition of TNF has led to significant clinical improvement. However, TNF-activated pathways and mechanisms involved in bone remodeling remain unclear. So far, TNF-α was known as an inhibitor of osteoblast differentiation and an activator of osteoclastogenesis. Recent contradictory findings indicated that TNF-α can also activate osteoblastogenesis. The paradoxical role of TNF-α in bone homeostasis seems to depend on the concentration and the differentiation state of the cell type used as well as on the exposure time. This review aims to summarize the recent contradictory findings on the regulation of bone homeostasis by TNF-α at the isolated cell, whole bone, and whole body levels. In addition, the involvement of TNF-α in the bone remodeling imbalance is observed in inflammatory joint diseases including rheumatoid arthritis and ankylosing spondylitis, which are associated with bone destruction and ectopic calcified matrix formation, respectively. Both diseases are associated with systemic/vertebral osteoporosis.
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影响因子：
4.8
作者：
Gilbert, L;He, XF;Nanes, MS
通讯作者：
Nanes, MS
影响因子：
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作者：
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作者：
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影响因子：
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作者：
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通讯作者：
Zwerina J
DOI：
10.1016/j.bbrc.2012.12.036
发表时间：
2013-01-18
影响因子：
3.1
作者：
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通讯作者：
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