Enamel demineralization and the length of intra-oral exposure to different concentrations of glucose or sucrose.
Enamel demineralization and the length of intra-oral exposure to different concentrations of glucose or sucrose.
复制标题
牙釉质脱矿和口腔内暴露于不同浓度的葡萄糖或蔗糖的时间长短。
DOI：
10.1177/00220345860650021001
复制
发表时间：
1986
影响因子：
7.6
通讯作者：
Attarzadeh,F
中科院分区：
文献类型：
--
作者：
Tehrani,A;Goulet,D;Brudevold,F;Attarzadeh,F
六名受试者佩戴带有八块牛牙釉质块的口腔内装置，这些牙釉质块上覆盖着一层变形链球菌。他们用 5% 或 10% 葡萄糖 (G) 溶液漱口五秒、一分钟或一分钟的倍数。 45 分钟后，通过测定牙釉质碘化物渗透性 (ΔIp) 的变化来测量脱矿量。此外，在测试期间每隔一定时间采集唾液样本，分析 G，并计算清除时间 (tc)。 10% G 溶液的脱矿分数 (ΔIp) 始终高于 5% G 溶液。随着冲洗时间 (tr) 的增加，两种溶液的 ΔIp 都会增加。冲洗后残留在唾液中的 G 对 ΔIp 没有显着影响。 ΔIp 得分与变形链球菌细胞团的最终 pH 值显示出良好的相关性，r= -0.77。对于每种冲洗溶液，分数还显示出与 tr（r=0.87 和 0.79）的良好相关性，以及与 tr+ tc（r=0.44 和 0.53）的较弱相关性。体外连续暴露于 1%、5% 或 10% 蔗糖 (S) 唾液溶液 30 分钟或更长时间，导致 ΔIp 随时间线性增加，且无浓度影响。当每 30 分钟用 10% S 溶液漱口一分钟时，体内也观察到线性增加。研究结果表明，食用碳水化合物食物时可能会发生显着的脱矿质，并且饭后刷牙或漱口可能并不像人们普遍认为的那样有效预防龋齿。
Six subjects wore intra-oral devices carrying eight bovine enamel blocks which were covered with a layer of S. mutans. They rinsed their mouths for five sec, one min, or multiples of one min with a 5 or 10% glucose (G) solution. Demineralization was measured after 45 min by determining the change in iodide permeability (ΔIp) of the enamel. In addition, saliva samples, taken at intervals during the test, were analyzed for G, and the time of clearance (tc) was calculated. Demineralization scores (ΔIp) were consistently greater from the 10% than from the 5% G solution. Both solutions produced an increase in ΔIp with an increase in the rinsing time (tr). The G remaining in saliva after the rinse did not significantly affect ΔIp. The ΔIp scores showed good correlation with the final pH of the S. mutans cell mass, r= -0.77. For each rinse solution, the scores also showed good correlations with tr(r=0.87 and 0.79) and much weaker correlations with tr+ tc(r=0.44 and 0.53). Continuous in vitro exposure to 1, 5, or 10% solutions of sucrose (S) in saliva for 30 min or more caused a linear increase in ΔIp with time with no concentration effects. A linear increase was also observed in vivo when a one-minute mouth-rinse with 10% solution of S was administered every 30 min. The findings indicate that significant demineralization may occur while carbohydrate foods are consumed, and that brushing the teeth or rinsing the mouth after meals may not be as effective against caries as is generally believed.