Presynaptic receptors
Presynaptic receptors
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突触前受体
作者：
S. Langer
在过去的几年里，通过积累证据证明存在神经递质的突触前受体，除了经典的突触后受体介导效应器官(在外周)或突触后神经元的反应(在中枢神经系统)之外，对神经末梢和突触发生的经典图像进行了修改。突触前受体位于释放神经递质的神经末梢的外表面，被认为通过神经递质调节自身释放的负反馈机制参与刺激引起的神经递质释放的调制。正如美国冯·欧拉(斯德哥尔摩卡罗林斯卡研究所)在第一届突触前受体国际研讨会上的开幕演讲中指出的那样，突触前受体存在的第一个迹象可以
THE classical picture of events at nerve endings and synapses has been modified over the past few years by accumulating evidence for the existence of presynaptic receptors for neurotransmitters, in addition to the classical postsynaptic receptors which mediate the response of the effector organ (in the periphery) or of the postsynaptic neurone (in the central nervous system). The presynaptic receptors, found on the outer surface of the nerve endings from which neurotransmitter is released, are thought to be involved in the modulation of the neurotransmitter release evoked by stimulation, by means of a negative feedback mechanism in which a neurotransmitter regulates its own release. As US von Euler (Karolinska Institute, Stockholm) pointed out in his opening lecture at the First International Symposium on Presynaptic Receptors*, the first indications of the existence of presynaptic receptors can