Sex steroid hormones and the neural control of breathing
Sex steroid hormones and the neural control of breathing
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DOI：
10.1016/s1569-9048(03)00086-7
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发表时间：
2003-07-16
影响因子：
2.3
通讯作者：
Mitchell, GS
中科院分区：
文献类型：
--
作者：
Behan, M;Zabka, AG;Mitchell, GS
我们回顾了包括雌激素、黄体酮和睾酮在内的性类固醇激素参与呼吸中枢神经控制的证据。性激素可能通过神经调节剂，特别是血清素能系统，对呼吸运动神经元产生影响。最近的研究表明，雌性大鼠舌下核和膈核中的血清素（5HT）水平高于雄性大鼠。在雄性和雌性大鼠中，舌下和膈肌运动输出的血清素依赖性可塑性也不同。在整个发情周期中，性腺激素水平的变化与呼吸运动核中5HT水平的变化相一致，雄性大鼠的性腺切除术导致呼吸运动输出中5HT依赖的可塑性降低。我们推测，性类固醇激素在整个生命过程中对呼吸神经控制的适应起着至关重要的作用，随着年龄的增长，这些激素水平的降低可能会对呼吸控制系统产生负面影响，以应对挑战。(C) 2003 Elsevier Science B.V.版权所有
We review evidence that sex steroid hormones including estrogen, progesterone and testosterone are involved in the central neural control of breathing. Sex hormones may exert their effects on respiratory motoneurons via neuromodulators, in particular, the serotonergic system. Recent studies have shown that levels of serotonin (5HT) in the hypoglossal and phrenic nuclei are greater in female than in male rats. Serotonin-dependent plasticity in hypoglossal and phrenic motor output also differs in male and female rats. Changing levels of gonadal hormones throughout the estrus cycle coincide with changing levels of 5HT in respiratory motor nuclei, and gonadectomy in male rats results in a decrease in 5HT-dependent plasticity in respiratory motor output. We speculate that sex steroid hormones are critically involved in adaptations in the neural control of breathing throughout life, and that decreasing levels of these hormones with increasing age may have a negative influence on the respiratory control system in response to challenge. (C) 2003 Elsevier Science B.V. All rights reserved.