Cancer stem cells in lung cancer: Evidence and controversies.
Cancer stem cells in lung cancer: Evidence and controversies.
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DOI：
10.1111/resp.12094
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发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
Watkins DN
中科院分区：
文献类型：
--
作者：
Alamgeer M;Peacock CD;Matsui W;Ganju V;Watkins DN
癌症干细胞（CSC）模型是基于无数的实验和临床观察，这些观察表明恶性表型由一个细胞亚群维持，该细胞亚群的特征在于自我更新、分化和对化疗和放射的先天抗性。CSC可能是决定性治疗后疾病复发的原因，因此在功能上可能与微小残留病同义。与其他实体瘤相似，已经鉴定了肺CSC的几种推定的表面标志物，包括CD 133和CD 44。此外，细胞质酶醛脱氢酶ALDH的表达和/或活性以及细胞排除膜渗透性染料（称为“侧群”）的能力与体外和体内的干细胞样功能相关。胚胎干细胞途径如Hedgehog、Notch和WNT也可能在肺癌干细胞中具有活性，因此在对手术、放疗或化疗实现完全反应的患者中，可以在治疗上靶向用于维持治疗。本文将回顾有关肺CSC的存在和功能的实验和临床证据的背景下，并讨论一些正在进行的争议，关于这个模型的证据。
The cancer stem cell (CSC) model is based on a myriad of experimental and clinical observations suggesting that the malignant phenotype is sustained by a subset of cells characterized by the capacity for self-renewal, differentiation and innate resistance to chemotherapy and radiation. CSC may be responsible for disease recurrence after definitive therapy and may therefore be functionally synonymous with minimal residual disease. Similar to other solid tumours, several putative surface markers for lung CSC have been identified, including CD133 and CD44. In addition, expression and/or activity of the cytoplasmic enzyme aldehyde dehydrogenase ALDH and capacity of cells to exclude membrane permeable dyes (known as the ‘side population’) correlate with stem-like function in vitro and in vivo. Embryonic stem cell pathways such as Hedgehog, Notch and WNT may also be active in lung cancers stem cells and therefore may be therapeutically targetable for maintenance therapy in patients achieving a complete response to surgery, radiotherapy or chemo-therapy. This paper will review the evidence regarding the existence and function of lung CSC in the context of the experimental and clinical evidence and discuss some ongoing controversies regarding this model.
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影响因子：
4.8
作者：
He, B;You, L;Jablons, DM
通讯作者：
Jablons, DM
影响因子：
8
作者：
Dang, TP;Eichenberger, S;Carbone, DP
通讯作者：
Carbone, DP
影响因子：
12.4
作者：
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通讯作者：
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DOI：
10.1073/pnas.0603806103
发表时间：
2006-08-01
影响因子：
11.1
作者：
Chute, John P.;Muramoto, Garrett G.;McDonnell, Donald P.
通讯作者：
McDonnell, Donald P.
影响因子：
3.7
作者：
Chen, Yu-Chih;Hsu, Han-Shui;Chen, Yi-Wei;Tsai, Tung-Hu;How, Chorng-Kuang;Wang, Chien-Ying;Hung, Shih-Chieh;Chang, Yuh-Lih;Tsai, Ming-Long;Lee, Yi-Yen;Ku, Hung-Hai;Chiou, Shih-Hwa
通讯作者：
Chiou, Shih-Hwa