Single nucleotide polymorphisms in PDCD6 gene are associated with the development of cervical squamous cell carcinoma
Single nucleotide polymorphisms in PDCD6 gene are associated with the development of cervical squamous cell carcinoma
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PDCD6基因单核苷酸多态性与宫颈鳞癌的发生有关
DOI：
10.1007/s10689-014-9767-7
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Lin Zhang
中科院分区：
文献类型：
--
作者：
Kana Wang;Yi Quan;Yaping Song;Lin Zhang
程序性细胞死亡6（PDCD6）作为一种促凋亡的钙结合蛋白被发现，近期发现在多种来源的肿瘤中失调，并有助于癌细胞的存活。本研究的目的是确定PD中的单核苷酸多态性（SNPs）是否……
The programmed cell death 6 (PDCD6), discovered as a proapoptotic calcium-binding protein, has recently been found dysregulated in tumors of various origin and contributed to cancer cell viability. The aim of this study was to determine whether SNPs in PDCD6 are associated with cervical squamous cell carcinoma (CSCC). Polymerase chain reaction-restriction fragment length polymorphism method was used to genotype two tag SNPs (rs3756712 and rs4957014) of PDCD6 in 328 CSCC patients and 541 controls. Significantly increased CSCC risks were found to be associated with T allele of rs3756712 and G allele of rs4957014 (P = 0.017, OR = 1.320, and P = 0.007, OR = 1.321, respectively). CSCC risks were associated with these two SNPs in different genetic model (P = 0.04, OR = 1.78 for rs3756712 in a recessive model, and P = 0.006, OR = 2.01 for rs4957014 in a codominant model, respectively). Results of stratified analyses revealed that rs4957014 is associated with parametrial invasion of CSCC (P = 0.044, OR = 1.414). Our results suggest that these two tag SNPs of PDCD6 are associated with CSCC, indicating that PDCD6 may play an important role in the pathogenesis of CSCC.
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影响因子：
5.8
作者：
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