Fear conditioning to tone, but not to context, is attenuated by lesions of the insular cortex and posterior extension of the intralaminar complex in rats
Fear conditioning to tone, but not to context, is attenuated by lesions of the insular cortex and posterior extension of the intralaminar complex in rats
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DOI：
10.1037//0735-7044.115.2.365
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发表时间：
2001-04-01
影响因子：
1.9
通讯作者：
Kim, JJ
中科院分区：
文献类型：
--
作者：
Brunzell, DH;Kim, JJ
C. Shi和M. Davis（1999）最近报道，板内复合体（PINT）和尾侧岛叶皮质（INS）的后延伸的联合损伤阻断了对离散条件刺激（CS）和足底电击非条件刺激（US）的恐惧增强惊吓的获得，但不阻断恐惧增强惊吓的表达，并提出PINT-INS向杏仁核的投射构成了参与恐惧条件反射的重要US通路。本研究进一步验证了这一假设，检查是否PINT-INS病变块恐惧条件反射（冻结测量）扩散的背景和离散音CS，以及是否posttraining病变与持续CS-US训练的结果灭绝的CS。训练后的病变导致选择性衰减的色调条件反射，但上下文条件反射不受训练前和训练后病变。这些结果不支持PINT-INS代表恐惧条件反射中的基本US通路的观点。
C. Shi and M. Davis (1999) recently reported that combined lesions of the posterior extension of the intralaminar complex (PINT) and caudal insular cortex (INS) block acquisition but not expression of fear-potentiated startle to discrete conditioned stimuli (CSs) and a footshock unconditioned stimulus (US) and proposed that PINT-INS projections to the amygdala constitute the essential US pathways involved in fear conditioning. The present study further tested this hypothesis by examining whether PINT-INS lesions block fear conditioning (as measured by freezing) to diffuse-context and discrete-tone CSs, and whether posttraining lesions with continued CS-US training result in extinction to the CSs. Posttraining lesions resulted in a selective attenuation of tone conditioning, but context conditioning was unaffected by pre- and posttraining lesions. These results do not support the view that the PINT-INS represent the essential US pathway in fear conditioning.