Noncancer disease incidence in atomic bomb survivors, 1958-1998
Noncancer disease incidence in atomic bomb survivors, 1958-1998
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DOI：
10.1667/rr3183
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发表时间：
2004-06-01
影响因子：
3.4
通讯作者：
Suzuki, G
中科院分区：
文献类型：
--
作者：
Yamada, M;Wong, FL;Suzuki, G
我们利用1958-1998年间约10,000名成人健康研究（AHS）参与者的纵向数据，研究了非癌症疾病发病率与原子弹辐射剂量之间的关系。本报告更新了我们1993年提出的分析，增加了12年的后续行动。除了先前在甲状腺疾病（P < 0.0001）、慢性肝病和肝硬化（P = 0.001）和子宫肌瘤（P < 0.00001）的发病率中发现具有统计学意义的正线性剂量-反应关系外，我们还发现白内障（P = 0.026）的发病率呈显著的正剂量反应关系，青光眼（P = 0.025）呈负线性剂量-反应关系。在40岁以下暴露的幸存者中，高血压（P = 0.028）和心肌梗死（P = 0.049）存在显著的二次剂量-反应关系。辐射对肾结石和输尿管结石的显著影响在男性中很明显，但在女性中没有（性别异质性检验：P = 0.007）。考虑到吸烟和饮酒并没有改变结果。辐射对男性白内障、青光眼、高血压、肾结石和输尿管的影响是新的发现。这些结果证明，需要继续对老年原子弹幸存者进行随访，以充分阐明辐射照射对非癌症疾病发生的影响。(C) 2004年由辐射研究学会主办。
We examined the relationships between the incidence of noncancer diseases and atomic bomb radiation dose using the longitudinal data for about 10,000 Adult Health Study (AHS) participants during 1958-1998. The current report updates the analysis we presented in 1993 with 12 additional years of follow-up. In addition to the statistically significant positive linear dose-response relationships detected previously for the incidence of thyroid disease (P < 0.0001), chronic liver disease and cirrhosis (P = 0.001), and uterine myoma (P < 0.00001), we also found a significant positive dose response for cataract (P = 0.026), a negative linear dose-response relationship for glaucoma (P = 0.025), and significant quadratic dose-response relationships for hypertension (P = 0.028) and for myocardial infarction among survivors exposed at less than 40 years of age (P = 0.049). Significant radiation effects for calculus of the kidney and ureter were evident for men but not for women (test of heterogeneity by sex: P = 0.007). Accounting for smoking and drinking did not alter the results. Radiation effects for cataract, glaucoma, hypertension, and calculus of the kidney and ureter in men are new findings. These results attest to the need for continued follow-up of the aging A-bomb survivors to fully elucidate the effects of radiation exposure on the occurrence of noncancer diseases. (C) 2004 by Radiation Research Society.