Effect of broad-spectrum parenteral antibiotics on "colonization resistance" of intestinal microflora of humans
Effect of broad-spectrum parenteral antibiotics on "colonization resistance" of intestinal microflora of humans
复制标题
广谱肠外抗生素对人类肠道菌群“定植抗性”的影响
DOI：
10.1128/aac.31.5.723
复制
发表时间：
1987
影响因子：
4.9
通讯作者：
S. Gorbach
中科院分区：
文献类型：
--
作者：
M. Barza;M. Giuliano;N. Jacobus;S. Gorbach
对动物的研究表明，正常的肠道微生物菌群可以防止新菌株的定植（“定植抗性”），这种保护作用可能与微生物菌群的厌氧成分有关。然而，在人类中尚未显示出殖民抗性。我们给健康受试者静脉注射头孢西丁、哌拉西林、头孢哌酮和氨曲南9天，并监测粪便植物群中新分离株的获得。16名接受抗生素治疗的受试者中有7名被革兰氏阴性杆菌定植，而4名未接受治疗的对照者中无一例被革兰氏阴性杆菌定植。然而，定植与给予的特定药物或厌氧菌或粪便微生物群落的任何其他组分的抑制程度之间没有相关性。头孢西丁和哌拉西林与耐药菌数量和粪便β-内酰胺酶含量的最大增加相关。这项研究的结果支持了人类中发生的定植耐药性的概念，并通过抗生素给药减少，但未能支持耐药性与厌氧微生物区系有关的假设。
Studies with animals have shown that the normal intestinal microflora protects against colonization by new strains ("colonization resistance") and that this protective effect may be related to the anaerobic component of the microflora. However, colonization resistance has not been shown in humans. We administered cefoxitin, piperacillin, cefoperazone, and aztreonam intravenously to healthy subjects for 9 days and monitored the acquisition of new isolates in the fecal flora. Seven of sixteen antibiotic-treated subjects but none of four untreated controls became colonized by gram-negative bacilli. However, there was no correlation between colonization and the particular drug given or the extent of suppression of anaerobes or of any other component of the fecal microflora. Cefoxitin and piperacillin were associated with the greatest increases in the numbers of drug-resistant bacteria and in fecal beta-lactamase content. The results of this study support the concept that colonization resistance occurs in humans and is diminished by antibiotic administration but fail to support the hypothesis that resistance is related to the anaerobic microflora.