The neuroprotective role of SIRT1/PGC-1α signaling in limb postconditioning in cerebral ischemia/reperfusion injury
The neuroprotective role of SIRT1/PGC-1α signaling in limb postconditioning in cerebral ischemia/reperfusion injury
复制标题
SIRT1/PGC-1α信号在脑缺血/再灌注损伤肢体后处理中的神经保护作用
DOI：
10.1016/j.neulet.2021.135736
复制
发表时间：
2021-02-24
影响因子：
2.5
通讯作者：
Li，Hao
中科院分区：
文献类型：
--
作者：
Li，Li;Zhi，Dongyi;Li，Hao
亮点LPostC上调缺血皮质组织中SIRT1和PGC-1α蛋白表达。LPostC后SIRT1/PGC-1α信号通路抑制增加大鼠脑梗死体积并加重神经功能缺损。LPostC后SIRT1/PGC-1α信号通路抑制增加大鼠神经元凋亡和氧化应激 LPostC.LPosC 可能至少部分通过上调 SIRT1/PGC-1α 信号通路来预防脑 IRI。
HighlightsLPostC up-regulated the SIRT1 and PGC-1α protein expressions in ischemic cortical tissue.SIRT1/PGC-1α signaling pathway inhibition increased cerebral infarction volume and aggravated neurological deficits in rats after LPostC.SIRT1/PGC-1α signaling pathway inhibition increased neuronal apoptosis and oxidative stress in rats after LPostC.LPosC may protect against cerebral IRI at least in part via up-regulating the SIRT1/PGC-1α signaling pathway.