Is speed of processing or working memory the primary information processing deficit in multiple sclerosis?
Is speed of processing or working memory the primary information processing deficit in multiple sclerosis?
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DOI：
10.1080/13803390490496641
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发表时间：
2004-06-01
影响因子：
2.2
通讯作者：
Chiaravalloti, ND
中科院分区：
文献类型：
--
作者：
DeLuca, J;Chelune, GJ;Chiaravalloti, ND
目的：探讨多发性硬化症患者的主要信息加工缺陷是加工速度还是工作记忆。环境：医院为基础的专科诊所。研究对象：215名临床确诊多发性硬化症的成年人。主要结果测量：平均人口统计学校正的t评分、损伤的患病率和来自WAIS-WMS III的处理速度和工作记忆指数得分受损的相对风险。结果：在所有比较中，处理速度缺陷比工作记忆缺陷更为普遍。在复发缓解型（RRMS）和继发性进展型MS （SPMS）受试者中均观察到这种情况，但在后一组中更为突出。结论：MS患者的主要信息加工缺陷表现在加工速度上。
Objective: To examine whether processing speed or working memory is the primary information processing deficit in persons with MS. Design: Case-control study. Setting: Hospital-based specialty clinic. Participants: 215 adults with clinically definite MS. Main Outcome Measure: Mean demographically corrected T-scores, prevalence rates of impairment and relative risk of impaired Processing Speed and Working Memory Index Scores from the WAIS-WMS III. Results: Deficits in Processing Speed were much more common than Working Memory in all comparisons. This was observed for both relapsing remitting (RRMS) and secondary progressive MS (SPMS) subjects, but accentuated in the latter group. Conclusions: Results strongly suggest that the primary information processing deficit in persons with MS is in speed of processing.