PSYCHOSOCIAL STRESS AS A RISK FOR BREAST-CANCER
PSYCHOSOCIAL STRESS AS A RISK FOR BREAST-CANCER
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DOI：
10.1159/000288427
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发表时间：
1991-01-01
影响因子：
22.8
通讯作者：
FORSEN, A
中科院分区：
文献类型：
--
作者：
FORSEN, A
对87例乳腺癌患者及其对照进行了生活事件、重要情感损失、困难生活情境和心理特征的病例对照研究。 在第二部分中，在乳腺癌组的8年随访中研究了癌症诊断前的压力生活事件对生存率的影响。 对照组选自一般女性人群，性别、年龄、分娩次数和语言相匹配。 研究结果表明，乳腺癌患者在发现乳腺肿瘤之前比对照组有更多的生活事件，重大损失和困难的生活状况。 分析表明，在6年的前驱期和生活事件评分检查前的12个月和修改后的6年社会再适应评定量表的重要损失与随后的乳腺癌的发展。 在调整了婚姻状况、教育和社会阶层后，这种关联仍然存在。 生存分析的结果表明，在控制临床因素后，乳腺癌发病前12个月内的生活事件和较低的社会阶层与无病生存和总生存的机会较小相关。
Life events, important emotional losses, difficult life situations, and psychological characteristics were investigated in a case-control study of 87 breast cancer patients and their controls. In a second part, the effect of stressful life events preceding cancer diagnosis on survival was studied in an 8-year follow-up of the breast cancer group. The control group was selected from the general female population and matched for sex, age, number of childbirths, and language. The findings showed that breast cancer patients had significantly more life events, important losses, and difficult life situations prior to the discovery of the breast tumor than controls. The analysis indicated that important losses during a 6-year prodromal period and life event scores prior to examination on both the 12-month and modified 6-year Social Readjustment Rating Scale were associated with subsequent development of breast cancer. The association persisted after adjustment for marital status, education, and social class. The findings of the survival analyses indicated that life events in the 12 months preceding the onset of breast cancer and lower social class were associated with a smaller chance of disease-free and overall survival after controlling for clinical factors.