High levels of cytokine-producing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome
High levels of cytokine-producing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome
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DOI：
10.1086/314597
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发表时间：
1999-02-01
影响因子：
6.4
通讯作者：
Ennis, FA
中科院分区：
文献类型：
--
作者：
Mori, M;Rothman, AL;Ennis, FA
汉坦病毒肺综合征（HPS）的特点是肺水肿发病快、病死率高。汉坦病毒抗原已在肺毛细血管内皮细胞中得到证实，但引起毛细血管渗漏的机制仍不清楚。使用免疫组织化学染色来计数 HPS 受试者尸检时获得的组织中产生细胞因子的细胞（单核细胞：白细胞介素 [IL]-1 α、IL-1 β、IL-6 和肿瘤坏死因子 [TNF]-α；淋巴因子：干扰素-γ、IL-2、IL-4 和 TNF-β）。 HPS 患者的肺和脾组织中发现大量产生细胞因子的细胞，但肝脏和肾脏中的细胞数量很少。在死于非 HPS 急性呼吸窘迫综合征 (ARDS) 的患者肺部中检测到产生细胞因子的细胞数量适度增加，而在死于非 ARDS 的患者肺部中检测到很少（或没有）产生细胞因子的细胞。这些结果表明，局部细胞因子的产生可能在 HPS 的发病机制中发挥重要作用。
Hantavirus pulmonary syndrome (HPS) is characterized by the rapid onset of pulmonary edema and a high case-fatality rate. Hantavirus antigens have been demonstrated in pulmonary capillary endothelial cells, but the mechanisms causing capillary leakage remain unclear. Immunohistochemical staining was used to enumerate cytokine-producing cells (monokines: interleukin [IL]-1 alpha, IL-1 beta, IL-6, and tumor necrosis factor [TNF]-alpha; lymphokines: interferon-gamma, IL-2, IL-4, and TNF-beta) in tissues obtained at autopsy from subjects with HPS. High numbers of cytokine-producing cells were seen in the lung and spleen tissues of HPS patients, but only low numbers in the livers and kidneys. A modest increase in the numbers of cytokine-producing cells was detected in the lungs of patients who died with non-HPS acute respiratory distress syndrome (ARDS), and very few (or no) cytokine-producing cells were detected in the lungs of patients who died of causes other than ARDS, These results suggest that local cytokine production may play an important role in the pathogenesis of HPS.