The contribution of bone loss to postmenopausal osteoporosis.
The contribution of bone loss to postmenopausal osteoporosis.
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DOI：
10.1007/bf01880413
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发表时间：
1990-10-01
期刊：
影响因子：
--
通讯作者：
Johnston, C C Jr
中科院分区：
文献类型：
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作者：
Hui, S L;Slemenda, C W;Johnston, C C Jr
我们通过对健康的白色绝经后妇女的各种样本进行纵向测量，研究了峰值骨量和随后的丢失率在确定绝经后妇女老年骨量方面的相对重要性。使用年龄特异性骨丢失率的方差估计和骨量的群体方差，我们确定丢失率对未来骨量有重要贡献。然而，由于我们发现初始骨量和丢失率之间存在较小的负相关性，因此有必要估计骨丢失的影响，作为初始骨量贡献的补充。我们发现，骨丢失的影响（相对于初始骨量）随着女性年龄的增长而增加，例如到70岁左右，初始骨量和丢失率的贡献接近相等。然而，随着时间的推移，估计的骨质流失率并不是很稳定，因此很难确定长期的“快速流失者”。我们的结论是，绝经后骨质流失率是老年骨质疏松症的一个重要因素，但很难确定长期的快速失败者，从而降低了绝经后早期骨量变化率评估的临床价值。
We have addressed the relative importance of peak bone mass and subsequent rate of loss in determining postmenopausal women's bone mass in old age, by examining longitudinal measurements of radial mid-shaft bone mass on various samples of healthy white postmenopausal women. Using both the variance estimate of age-specific rates of bone loss and the population variance in bone mass, we determined that rates of loss could contribute importantly to future bone mass. However, since we found a small negative correlation between initial bone mass and rate of loss, it was necessary to estimate the effect of bone loss as the complement of the contribution of initial bone mass. We found that the influence of bone loss (relative to initial bone mass) increases as the women age, such that by about age 70, the contribution of initial bone mass and rate of loss approached equality. However, estimated rates of bone loss were not very stable over time, so it was difficult to identify long-term 'fast-losers'. We conclude that the rate of postmenopausal bone loss is an important contributor to osteoporosis at old age, but it is difficult to identify long-term fast-losers, thereby reducing the clinical value of assessments of rates of change in bone mass early in the postmenopause.