Geometric systematic prostate biopsy
Geometric systematic prostate biopsy
复制标题
几何系统前列腺活检
DOI：
10.1080/13645706.2016.1249890
复制
发表时间：
2017
影响因子：
1.7
通讯作者：
D. Stoianovici
中科院分区：
文献类型：
--
作者：
Doyoung Chang;Xue Chong;Chunwoo Kim;Changhan Jun;D. Petrisor;Misop Han;D. Stoianovici
摘要目的：常见的六分仪前列腺活检方案缺乏三维（3D）几何定义。研究目的是确定核心的几何分布对前列腺癌（PCa）检测概率的影响。研究方法：基于活检样本的新型3D胶囊模型，量化显著（>0.5 cm 3）和不显著（<0.2 cm 3）肿瘤的检测概率。对芯的几何分布进行了优化，以最大限度地提高经直肠和经会阴活检的各种前列腺尺寸（20- 100 cm 3）、活检芯数量（6-40芯）和活检芯长度（14-40 mm）的显著癌症检测概率。结果：通过几何优化可以提高显著癌症的检测。对于目前的六分活检，由于该模式，在20 cm 3前列腺中活检时可能会遗漏高达20%的肿瘤。在较大的前列腺中，需要更高数量和更长的活检芯以相同的检测概率进行采样。更高数量的核增加了显著和不显著的肿瘤检测概率，但主要增加了不显著肿瘤的检测。结论：该研究从数学上证明了几何活检方案在临床上起着重要的作用，并且增加活检芯的数量不一定有帮助。
Abstract Objective: The common sextant prostate biopsy schema lacks a three-dimensional (3D) geometric definition. The study objective was to determine the influence of the geometric distribution of the cores on the detection probability of prostate cancer (PCa). Methods: The detection probability of significant (>0.5 cm3) and insignificant (<0.2 cm3) tumors was quantified based on a novel 3D capsule model of the biopsy sample. The geometric distribution of the cores was optimized to maximize the probability of detecting significant cancer for various prostate sizes (20–100cm3), number of biopsy cores (6–40 cores) and biopsy core lengths (14–40 mm) for transrectal and transperineal biopsies. Results: The detection of significant cancer can be improved by geometric optimization. With the current sextant biopsy, up to 20% of tumors may be missed at biopsy in a 20 cm3 prostate due to the schema. Higher number and longer biopsy cores are required to sample with an equal detection probability in larger prostates. Higher number of cores increases both significant and insignificant tumor detection probability, but predominantly increases the detection of insignificant tumors. Conclusion: The study demonstrates mathematically that the geometric biopsy schema plays an important clinical role, and that increasing the number of biopsy cores is not necessarily helpful.
前列腺活检和针疗法的技术进步。
DOI：
10.1016/j.juro.2012.06.127
发表时间：
2012
期刊：
The Journal of urology
影响因子：
--
作者：
Stoianovici,Dan
通讯作者：
Stoianovici,Dan
影响因子：
6.6
作者：
Han, Misop;Chang, Doyoung;Kim, Chunwoo;Lee, Brian J.;Zuo, Yihe;Kim, Hyung-Joo;Petrisor, Doru;Trock, Bruce;Partin, Alan W.;Rodriguez, Ronald;Carter, H. Ballentine;Allaf, Mohamad;Kim, Jongwon;Stoianovici, Dan
通讯作者：
Stoianovici, Dan