Adversity in preschool-aged children: Effects on salivary interleukin-1β.
Adversity in preschool-aged children: Effects on salivary interleukin-1β.
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DOI：
10.1017/s0954579415000164
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发表时间：
2015-05
影响因子：
3.3
通讯作者：
Seifer R
中科院分区：
文献类型：
--
作者：
Tyrka AR;Parade SH;Valentine TR;Eslinger NM;Seifer R
暴露于早期生活逆境与情感，认知和行为功能受损有关，并增加了各种精神病和医学疾病的风险。应激诱导的促炎细胞因子增加可能是这些作用的生物学机制。很少有研究检查经历早期生活逆境的儿童的细胞因子水平，也很少有研究调查唾液中的细胞因子或其他炎症标志物。在本研究中，我们检测了40名3至5岁儿童的唾液IL-1β和C-反应蛋白（CRP）水平与压力暴露的关系，这些儿童参加了一项大型的早期生活逆境研究。通过审查儿童福利记录评估儿童期虐待状况，并通过家庭访视时的护理人员访谈评估环境压力暴露、创伤性生活事件史和精神病理学症状。在随后的访问中，唾液IL-1β和CRP在参与四个情绪诱发任务之前和之后获得。过去一个月的环境压力源，终身环境压力源，创伤性生活事件的数量都证明了对IL-1β的显着的主效应。基线IL-1β与每种显著的主效应不良反应呈正相关。攻击后IL-1β与每个逆境变量呈正相关，但不显著。CRP与任何逆境变量均无显著相关性。鉴于有证据表明IL-1β参与精神疾病的神经病理学，这些结果可能对发育结局具有重要意义。
Exposure to early life adversity is linked to impaired affective, cognitive, and behavioral functioning and increases risk for various psychiatric and medical conditions. Stress-induced increases in pro-inflammatory cytokines may be a biological mechanism of these effects. Few studies have examined cytokine levels in children experiencing early life adversity, and very little research has investigated cytokines or other markers of inflammation in saliva. In the present study, we examined salivary IL-1β and C-reactive protein (CRP) levels in relation to stress exposure in 40 children aged 3 to 5 years who were enrolled in a larger study of early life adversity. Childhood maltreatment status was assessed via review of child welfare records, and contextual stress exposure, traumatic life event history, and symptoms of psychopathology were assessed via caregiver interviews at a home visit. In a subsequent visit, salivary IL-1β and CRP were obtained before and after participation in four emotion-eliciting tasks. Number of past month contextual stressors, lifetime contextual stressors, and traumatic life events each demonstrated a significant main effect on IL-1β. Baseline IL-1β was positively associated with each of the significant main-effect adversities. Post-challenge IL-1β displayed positive associations with each adversity variable, but were not significant. CRP was not significantly associated with any of the adversity variables. Given evidence suggesting involvement of IL-1β in the neuropathology of psychiatric conditions, these results may have important implications for developmental outcomes.