Successful Treatment of Invasive Conidiobolus Infection During Therapy for Acute Lymphoblastic Leukemia.
Successful Treatment of Invasive Conidiobolus Infection During Therapy for Acute Lymphoblastic Leukemia.
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DOI：
10.1097/mph.0000000000000985
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发表时间：
2018-10
期刊：
影响因子：
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通讯作者：
Harker-Murray P
中科院分区：
文献类型：
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作者：
Erker C;Huppler AR;Walsh TJ;McCormick ME;Suchi M;Bhatt NS;Kehl SC;Southwood J;Harker-Murray P
侵袭性真菌感染是恶性血液病患者发病率和死亡率的严重原因。分生孢子球菌属昆虫病原菌目的霉菌，可在免疫功能受损的个体中传播并迅速致死。这种真菌感染往往是多药耐药(MDR)，并提出了独特的治疗挑战。在儿科肿瘤学中，分生孢子球感染的报道很少见。我们报告了一例青少年男性B细胞淋巴母细胞性白血病和耐多药侵袭性鼻肺分生孢子虫感染的成功治疗，重点是早期和积极的中性粒细胞支持手术清创。所述策略也可应用于其他耐多药真菌感染。
Invasive fungal infections are a serious cause of morbidity and mortality in patients with hematologic malignancies. Conidiobolus species are molds within the order Entomophthorales and may disseminate to become rapidly fatal in immunocompromised individuals. This species of fungal infections are often multidrug resistant (MDR) and present unique therapeutic challenges. Reports of Conidiobolus infections are rare in pediatric oncology. We report the successful treatment of an adolescent male with B cell lymphoblastic leukemia and MDR invasive sinopulmonary Conidiobolus infection with emphasis on early and aggressive neutrophil support with surgical debridement. The strategies described could be applied to other MDR fungal infections.