Renewal of cells within taste buds.
Renewal of cells within taste buds.
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DOI：
10.1083/jcb.27.2.263
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发表时间：
1965-11
期刊：
影响因子：
--
通讯作者：
Smallman RL
中科院分区：
文献类型：
--
作者：
Beidler LM;Smallman RL
秋水仙碱阻断大鼠舌味蕾周围上皮细胞的有丝分裂。通过记录味觉神经束的电活动，秋水仙碱注射后3小时，对化学刺激的反应降低了50%。放射自显影术，使用氚标记的胸苷，显示味蕾周围的上皮细胞分裂，一些子细胞进入味蕾并慢慢向中心移动。平均电池的寿命约为250 ± 50小时，尽管有些电池的寿命短得多，而另一些电池的寿命长得多。这些研究表明，味蕾内的细胞以及神经随着时间的推移而发生相当大的变化。相应的功能变化被认为是。
Colchicine blocks mitotic division of the epithelial cells surrounding the taste bud of the rat tongue. Response to chemical stimulation decreases 50 per cent 3 hours after colchicine injection as measured by recording the electrical activity from the taste nerve bundle. Radioautography, using tritiated thymidine, shows that those epithelial cells surrounding the taste bud divide and that some of the daughter cells enter the taste bud and slowly move toward the center. The life span of the average cell is about 250 ± 50 hours, although some cells have a much shorter and others a much longer life span. These studies suggest that the cells within the taste bud, as well as the nerves, undergo considerable change with time. Corresponding changes in function are considered.