Cord serum 25-hydroxyvitamin D and risk of early childhood transient wheezing and atopic dermatitis
Cord serum 25-hydroxyvitamin D and risk of early childhood transient wheezing and atopic dermatitis
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DOI：
10.1016/j.jaci.2013.05.017
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发表时间：
2014-01-01
影响因子：
14.2
通讯作者：
Annesi-Maesano, Isabella
中科院分区：
文献类型：
--
作者：
Baiz, Nour;Dargent-Molina, Patricia;Annesi-Maesano, Isabella
工作背景：越来越多的证据表明，母亲在怀孕期间摄入维生素D对后代患哮喘和过敏性疾病的风险有影响。然而，关于脐带血中25-羟基维生素D水平与目的：探讨新生儿至5岁时脐带血25（OH）D水平与哮喘、哮鸣、过敏性鼻炎和特应性皮炎的关系。在出生时收集脐带血样本，并分析239名新生儿的25（OH）D水平，这些新生儿来自出生前和出生后发育和儿童健康（EDEN）研究组。儿童随访至5岁，使用国际研究哮喘和过敏儿童为基础的症状questionnaire.Results：中位数脐带血25（OH）D水平为17.8 ng/mL（四分位数间距，15.1 ng/mL）。通过使用多变量校正的逻辑回归模型，在1岁、2岁、3岁和5岁时，观察到脐带血清25（OH）D水平与一过性早期喘息、早发性和迟发性特应性皮炎以及特应性皮炎的风险之间存在显著的负相关。我们没有发现脐带血清25（OH）D水平与哮喘和过敏性鼻炎在5岁之间的关联。结论：脐带血清25（OH）D水平与短暂的早期喘息和特应性皮炎的风险呈负相关的5岁，但没有发现与哮喘和过敏性鼻炎。
Background: There is increasing evidence of the effect of maternal vitamin D intake during pregnancy on the risk of asthma and allergic outcomes in offspring. However, studies on the relationship between cord levels of 25-hydroxyvitamin D (25 [OH]D) and asthma and allergic diseases are very few.Objective: Our aim was to investigate the associations between cord serum25(OH)D levels and asthma, wheezing, allergic rhinitis, and atopic dermatitis in the offspring from birth to 5 years.Methods: Cord blood samples were collected at birth and analyzed for 25(OH)D levels in 239 newborns from the Etude des Determinants pre et post natals du developpement et de la sante de l'Enfant (EDEN) birth cohort. The children were followed up until age 5 years by using International Study of Asthma and Allergies in Childhood-based symptom questionnaires.Results: The median cord serum level of 25(OH)D was 17.8 ng/mL (interquartile range, 15.1 ng/mL). By using multivariable-adjusted logistic regression models, a significant inverse association was observed between cord serum 25(OH) D levels and risk of transient early wheezing and early-and late-onset atopic dermatitis, as well as atopic dermatitis, by the ages of 1, 2, 3, and 5 years. We found no association between cord serum 25(OH) D levels and asthma and allergic rhinitis at age 5 years.Conclusions: Cord serum 25(OH) D levels were inversely associated with the risk of transient early wheezing and atopic dermatitis by the age of 5 years, but no association was found with asthma and allergic rhinitis.