TRANSFERABLE RESISTANCE TO CEFOTAXIME, CEFOXITIN, CEFAMANDOLE AND CEFUROXIME IN CLINICAL ISOLATES OF KLEBSIELLA-PNEUMONIAE AND SERRATIA-MARCESCENS
TRANSFERABLE RESISTANCE TO CEFOTAXIME, CEFOXITIN, CEFAMANDOLE AND CEFUROXIME IN CLINICAL ISOLATES OF KLEBSIELLA-PNEUMONIAE AND SERRATIA-MARCESCENS
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DOI：
10.1007/bf01641355
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发表时间：
1983-01-01
期刊：
影响因子：
7.5
通讯作者：
MITSUHASHI, S
中科院分区：
文献类型：
--
作者：
KNOTHE, H;SHAH, P;MITSUHASHI, S
在结合杂交中，已证明三种肺炎杆菌菌株和粘质菌菌株可将耐药决定因素转移到新型头孢菌素。虽然lebsiellastres将头孢噻肟、头孢曼多和头孢呋辛抗性捐赠给大肠杆菌k -12受体，但将serratiastres的质粒转移到proteusor沙门氏菌受体后对共轭物的遗传分析表明，头孢噻肟抗性决定因素也被共同转移。在该质粒的后续转移循环中，头孢噻肟和头孢西丁耐药性决定因子分离，而在随后的转移循环中，来自克雷伯氏菌的质粒相对稳定。从本研究获得的结果可以得出结论，在某些医院肠杆菌科菌株中，对新型头孢菌素的耐药性可能是可传播的，因此可以定位质粒。
In conjugational crosses, threeKlebsiella pneumoniaestrains and oneSerratia marcescensstrain have been demonstrated to transfer resistance determinants to newer types of cephalosporins. WhileKlebsiellastrains donated cefotaxime, cefamandole and cefuroxime resistance toEscherichia coliK-12 recipients, the genetic analysis of exconjugants after the transfer of plasmids fromSerratiastrains toProteusorSalmonellarecipients showed that the cefoxitin resistance determinant was also co-transferred. In subsequent transfer cycles of this plasmid, cefotaxime and cefoxitin resistance determinants segregated in contrast to the relative stability of plasmids derived fromKlebsiellastrains in subsequent transfer cycles. From results obtained in this study, it may be concluded that in some strains of nosocomialEnterobacteriaceae, resistance to newer cephalosporins could be transmissible and thus plasmid-located.