Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight
Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight
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DOI：
10.1016/j.envres.2009.07.010
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发表时间：
2009-10-01
影响因子：
8.3
通讯作者：
Kishi, Reiko
中科院分区：
文献类型：
--
作者：
Konishi, Kanae;Sasaki, Seiko;Kishi, Reiko
一些人类研究表明，低水平接触环境污染物，如多氯联苯（PCB）和有机氯农药，对出生结果产生负面影响。本研究采用前瞻性队列研究方法，探讨了低剂量暴露于多氯二苯并二恶英（PCDDs）、多氯二苯并呋喃（PCDFs）和类二恶英多氯联苯（DL-PCBs）对胎儿生长发育和神经发育的影响。我们于2002年7月至2005年10月在日本札幌招募了514名孕妇。我们检测了29种PCDDs/PCDFs和DL-PCBs在孕妇血液中的浓度，并对出生体重与PCDDs/PCDFs和DL-PCBs浓度之间的关系进行了多元线性回归分析，并对潜在的混杂因素进行了充分调整，观察到了PCDDs总毒性当量（TEQ）水平的显著不利影响（调整后的β = -231.5克，95%氯：-417.4至-45.6）和多氯二苯并呋喃毒性当量总量（调整后的β = -258.8克，95%氯：-445.7至-71.8）。在男婴中，发现总多氯二苯并对二恶英毒性当量水平、总多氯二苯并对二恶英/多氯二苯并呋喃毒性当量水平和总毒性当量水平与出生体重存在显著的不利关联。然而，在女婴中，没有发现这些显著的不利关联。关于PCDDs/PCDFs和DL-PCBs的个别同源物，我们发现2，3，4，7，8-PeCDF的水平显著负相关（调整后的β = -24.5 g，95% Cl：我们的研究结果表明，产前低水平接触多氯二苯并对二恶英和多氯二苯并呋喃，特别是2，3，4，7，8-PeCDF，可能会在胎盘中积累并阻碍重要的胎盘功能，这导致出生体重较低。(C)2009 Elsevier Inc. All rights reserved.
Several human studies have shown that low-level exposure to environmental contaminants, such as polychlorinated biphenyls (PCBs) and organochlorine pesticides, negatively influences birth outcomes. However, the effects of low-level exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) on birth outcomes have not been clarified in human studies.A prospective cohort study was established to investigate the possible adverse effects of PCDDs/PCDFs and DL-PCBs on fetal growth and neurodevelopment. We recruited 514 pregnant women between July 2002 and October 2005 in Sapporo, Japan. We measured 29 congener levels of PCDDs/PCDFs and DL-PCBs in maternal blood.Using multiple liner regression analysis of the association between birth weight and the levels of PCDDs/PCDFs and DL-PCBs with full adjustments for potential confounders, a significant adverse effect was observed regarding total PCDDs toxic equivalents (TEQ) levels (adjusted beta = -231.5 g, 95% Cl: -417.4 to -45.6) and total PCDFs TEQ levels (adjusted beta = -258.8 g, 95% Cl: -445.7 to -71.8). Among male infants, significant adverse associations with birth weight were found for total PCDDs TEQ level, total PCDDs/PCDFs TEQ level, and total TEQ level. However, among female infants, these significant adverse associations were not found. With regard to individual congeners of PCDDs/PCDFs and DL-PCBs, we found significantly negative association with the levels of 2,3,4,7,8-PeCDF (adjusted beta = -24.5 g, 95% Cl: -387.4 to -61.5).Our findings suggest that prenatal low-level exposure to PCDDs and PCDFs, especially 2,3,4,7,8-PeCDF, may accumulate in the placenta and retard important placental functions, which result in lower birth weight. (C) 2009 Elsevier Inc. All rights reserved.