Use of serum albumin and activities of daily living to predict mortality in long-lived individuals over 95 years of age: a population-based study.
Use of serum albumin and activities of daily living to predict mortality in long-lived individuals over 95 years of age: a population-based study.
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DOI：
10.1007/s11357-015-9809-6
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发表时间：
2015-08-01
期刊：
影响因子：
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通讯作者：
Wang, Xiaofeng
中科院分区：
文献类型：
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作者：
Liu, Zuyun;Zhong, Guangzhen;Wang, Xiaofeng
日常生活活动 (ADL) 和一些血液生物标志物（如白蛋白）都与老年人的死亡率相关，但关于它们单独或组合的预测性能的数据很少，这对于临床医生的决策非常重要。在此，基于如皋长寿队列中 433 名 95 岁以上长寿个体 (LLI) 6 年随访期的前瞻性死亡率数据，我们旨在评估全因死亡率的 14 种生物标志物和 ADL 的 Cox 比例风险比 (HR) 和判别力（ROC 曲线）。我们发现六种生物标志物（总甘油三酯、白蛋白、低密度脂蛋白胆固醇、血小板计数、淋巴细胞计数和中性粒细胞计数）与死亡率相关，在单变量模型中 p < 0.10。当白蛋白和中性粒细胞计数同时纳入多变量模型时，观察到白蛋白和中性粒细胞计数与死亡率存在显着相关性，HR 分别为 0.97 (95% CI 0.94, 0.99; p = .005) 和 1.09 (95% CI 1.00, 1.18; p = .043)。对于 ADL，相应的 HR 为 1.10 (95% CI 1.07, 1.14；p < .001)。白蛋白低（
Both activities of daily living (ADL) and some blood biomarkers (such as albumin) have been associated with mortality in very elderly people, but scarce data is available on the predictive performance of them in isolation or in combination, which is important for clinicians in decision making. Here, based on prospective mortality data over a 6-year follow-up period from 433 long-lived individuals (LLIs) aged 95+ years in the Rugao longevity cohort, we aimed to evaluate Cox proportional hazard ratios (HRs) and discriminative power (ROC curve) of 14 biomarkers and ADL for all-cause mortality. We found that six biomarkers (total triglyceride, albumin, low-density lipoprotein cholesterol, platelet count, lymphocyte count, and neutrophil count) were associated with mortality with a p < .10 in the univariate model. Significant associations of albumin and neutrophil count with mortality were observed when they were simultaneously included in a multivariate model, with HRs of 0.97 (95 % CI 0.94, 0.99; p = .005) and 1.09 (95 % CI 1.00, 1.18; p = .043). With respect to ADL, the corresponding HR was 1.10 (95 % CI 1.07, 1.14; p < .001). Low albumin (